Hox targets and cellular functions.
Hox targets and cellular functions.
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DOI：
10.1155/2013/738257
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发表时间：
2013
期刊：
影响因子：
3.2
通讯作者：
Sánchez-Herrero E
中科院分区：
文献类型：
--
作者：
Sánchez-Herrero E
Hox基因是一组基因，其在双侧肌中沿前后轴沿着指定结构。虽然在许多情况下，它们是通过用不同的（或没有）Hox输入来修饰同源结构来实现的，但也有Hox基因在身体的其他区域中构建没有同源性的新器官的例子。Hox基因通过调节实现细胞功能的靶标和协调细胞行为来决定结构。构建或修饰某个器官的遗传组织涉及通过中间转录因子的遗传级联和对执行细胞功能的靶的直接调节。在这篇综述中，我将讨论来自全基因组技术的新数据，以及以前的遗传和发育信息，以描述Hox调控不同细胞功能的一些例子。我还讨论了导致新器官发育的遗传级联的组织，主要以果蝇为模型来分析Hox功能。
Hox genes are a group of genes that specify structures along the anteroposterior axis in bilaterians. Although in many cases they do so by modifying a homologous structure with a different (or no) Hox input, there are also examples of Hox genes constructing new organs with no homology in other regions of the body. Hox genes determine structures though the regulation of targets implementing cellular functions and by coordinating cell behavior. The genetic organization to construct or modify a certain organ involves both a genetic cascade through intermediate transcription factors and a direct regulation of targets carrying out cellular functions. In this review I discuss new data from genome-wide techniques, as well as previous genetic and developmental information, to describe some examples of Hox regulation of different cell functions. I also discuss the organization of genetic cascades leading to the development of new organs, mainly using Drosophila melanogaster as the model to analyze Hox function.