Reduced posterior mesofrontal cortex activation by risky rewards in substance-dependent patients
Reduced posterior mesofrontal cortex activation by risky rewards in substance-dependent patients
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DOI：
10.1016/j.drugalcdep.2007.12.014
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发表时间：
2008-05-01
影响因子：
4.2
通讯作者：
Hommer, Daniel W.
中科院分区：
文献类型：
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作者：
Bjork, James M.;Momenan, Reza;Hommer, Daniel W.
物质依赖的个人表现出不利的决策，以及在执行实验任务时改变额皮质招聘。我们研究了物质依赖患者（SDP）是否会表现出后中额叶皮层（PMC）的钝招募之间的冲突，同时增加奖励和惩罚的风险在金钱游戏的“鸡”。SDP和控制：运动控制（无奖励）试验，保证奖励试验中奖励没有风险，以及有风险的试验，其中要求受试者在秘密变化的时间限制之前终止奖励累积，否则“破产”并没收该试验的奖金（低罚款）或当前试验的奖金加上同等数量的先前奖金（高罚款）。奖励累积持续时间与特质神经质呈负相关。赢得保证奖励与非奖励之间的对比激活了SDP中的尾状头双侧，但不是控制。在低或高惩罚的风险下积累金钱（与积累保证金相比）激活了两组的PMC，但在控制组中具有更大的幅度和更前的程度。在低惩罚试验中，PMC感兴趣体积的决策前信号增加与风险承担负相关，并且在控制实际风险承担的个体差异和SDP的较高神经质后，在两种惩罚条件下相对于对照，SDP中的决策前信号增加变钝。这些数据表明，SDP的特征在于以下组合：（a）纹状体对奖赏的超敏反应，（B）当奖赏带来潜在的惩罚时，PMC的专门冲突监测电路招募不足。出版社：Elsevier爱尔兰Ltd.
Substance-dependent individuals show disadvantageous decision-making, as well as alterated frontocortical recruitment when performing experimental tasks. We investigated whether substance-dependent patients (SDP) would show blunted recruitment of posterior mesofrontal cortex (PMC) by a conflict between concurrently increasing reward and risk of penalty in a monetary game of "chicken." SDP and controls performed: motor control (no reward) trials, guaranteed reward trials in which reward was not at risk, and risky trials where subjects were required to terminate their reward accrual before a secret varying time limit or else "bust" and forfeit that trial's winnings (low penalty) or the current trial's winnings plus an equal amount of previous winnings (high penalty). Reward accrual duration at risk of "busting" correlated negatively with trait neuroticism. The contrast between winning guaranteed reward versus non-reward activated the caudate head bilaterally in SDP but not controls. Accumulation of money at risk of low- or high-penalty (contrasted with accumulating guaranteed money) activated the PMC in both groups, but with a greater magnitude and more anterior extent in controls. Pre-decision signal increase in a PMC volume of interest negatively correlated with risk-taking in low-penalty trials, and was blunted in SDP relative to controls under both penalty conditions after controlling for individual differences in actual risk-taking and the higher neuroticism of SDP These data suggest that SDP are characterized by a combination of: (a) striatal hypersensitivity to reward, and (b) under-recruitment of the specialized conflict-monitoring circuitry of the PMC when reward entails potential penalties. Published by Elsevier Ireland Ltd.