Dynamic 3D Chromatin Reorganization during Establishment and Maintenance of Pluripotency.
Dynamic 3D Chromatin Reorganization during Establishment and Maintenance of Pluripotency.
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DOI：
10.1016/j.stemcr.2020.10.012
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发表时间：
2020-12-08
影响因子：
5.9
通讯作者：
Apostolou E
中科院分区：
文献类型：
--
作者：
Pelham-Webb B;Murphy D;Apostolou E
Higher-order chromatin structure is tightly linked to gene expression and therefore cell identity. In recent years, the chromatin landscape of pluripotent stem cells has become better characterized, and unique features at various architectural levels have been revealed. However, the mechanisms that govern establishment and maintenance of these topological characteristics and the temporal and functional relationships with transcriptional or epigenetic features are still areas of intense study. Here, we will discuss progress and limitations of our current understanding regarding how the 3D chromatin topology of pluripotent stem cells is established during somatic cell reprogramming and maintained during cell division. We will also discuss evidence and theories about the driving forces of topological reorganization and the functional links with key features and properties of pluripotent stem cell identity. In this review article, Apostolou and colleagues discuss how the unique 3D chromatin architecture of pluripotent stem cells is established during somatic cell reprogramming and maintained during self-renewal. They analyze progress and gaps in our knowledge regarding the driving forces of 3D chromatin reorganization, the links to transcriptional changes and the impact on cell fate decisions.
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影响因子：
4
作者：
Apostolou E;Stadtfeld M
通讯作者：
Stadtfeld M
影响因子：
8.8
作者：
Behera, Vivek;Stonestrom, Aaron J.;Blobel, Gerd A.
通讯作者：
Blobel, Gerd A.
影响因子：
4
作者：
Calder, Ashley;Roth-Albin, Ivana;Draper, Jonathan S.
通讯作者：
Draper, Jonathan S.
影响因子：
64.5
作者：
Boija A;Klein IA;Sabari BR;Dall'Agnese A;Coffey EL;Zamudio AV;Li CH;Shrinivas K;Manteiga JC;Hannett NM;Abraham BJ;Afeyan LK;Guo YE;Rimel JK;Fant CB;Schuijers J;Lee TI;Taatjes DJ;Young RA
通讯作者：
Young RA
影响因子：
3.9
作者：
Dekker J
通讯作者：
Dekker J