A new antifungal macrolide, eushearilide, isolated from Eupenicillium shearii
A new antifungal macrolide, eushearilide, isolated from Eupenicillium shearii
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DOI：
10.1038/ja.2006.80
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发表时间：
2006-09-01
影响因子：
3.3
通讯作者：
Kawai, Ken-ichi
中科院分区：
文献类型：
--
作者：
Hosoe, Tomoo;Fukushima, Kazutaka;Kawai, Ken-ichi
在筛选抗真菌活性物质的过程中，从Shearii正青霉IFM54447中分离得到一个新的大环内酯类化合物eushearilide（1）。化合物1的结构经NMR、UV、IR、MS等波谱分析确定为24元大环内酯，具有非共轭二烯和磷酸胆碱酯结构。化合物1显示出对多种真菌和酵母的抗真菌活性，包括人类病原体烟曲霉、发癣菌属。和念珠菌属。
In screening for antifungal substances, a new macrolide, eushearilide (1), was isolated from Eupenicillium shearii IFM54447. The structure of 1 was established to be 24-membered macrolide having a non-conjugated diene and a choline phosphate ester moetiy on the basis of detailed investigation of NMR, UV, IR and MS spectral data. Compound 1 showed antifungal activity against various fungi and yeasts, including human pathogens Aspergillus fumigatus, Trichophyton spp. and Candida spp.