Memory and psychostimulants: modulation of Pavlovian fear conditioning by amphetamine in C57BL/6 mice.
Memory and psychostimulants: modulation of Pavlovian fear conditioning by amphetamine in C57BL/6 mice.
复制标题
记忆和精神兴奋剂：C57BL/6 小鼠中安非他明对巴甫洛夫恐惧调节的调节。
DOI：
10.1007/s00213-008-1185-9
复制
发表时间：
2009
影响因子：
3.4
通讯作者：
Anagnostaras,StephanG
中科院分区：
文献类型：
--
作者：
Wood,SuzanneC;Anagnostaras,StephanG
理论和目的随着处方兴奋剂的使用增加，重要的是检查低剂量和中等剂量的兴奋剂的认知影响，而不仅仅是那些典型的成瘾药物。材料和方法本研究考察了不同剂量(0.005-8 mg/kg)的硫酸苯丙胺对线索和背景巴甫洛夫恐惧条件作用小鼠的影响。结果与先前的研究一致，在戒毒测试中，服用中剂量苯丙胺(8 mg/kg)的受试者在训练前表现出受损的条件性冰冻，这是吸毒者可能服用的典型药物。或者，受试者在训练前注射非常低剂量的苯丙胺(0.005、0.025或0.05g/kg)，类似于治疗注意力缺陷多动障碍的剂量，在停药测试时表现出增强的记忆力。一项对照研究表明，这些影响不是由于状态依赖学习。结论因此，剂量是心理刺激剂认知效果的关键决定因素。
Rationale and objectivesWith the use of prescription stimulants on the rise, it is important to examine the cognitive effects of low and moderate doses of stimulants rather than only those typical of addicts.Materials and methodsThe present study examined the effects a range of doses (0.005–8 mg/kg) ofd-amphetamine sulfate on cued and contextual Pavlovian fear conditioning in mice.ResultsIn agreement with previous research, subjects administered with a moderately high dose of amphetamine (8 mg/kg) pre-training, typical of what addicts might take, displayed impaired conditioned freezing when tested off-drug. Alternately, subjects injected with a very low dose of amphetamine (0.005, 0.025, or 0.05 mg/kg) pre-training, similar to the therapeutic doses for attention deficit hyperactivity disorder, displayed enhanced memory when tested off-drug. A control study showed that these effects were not due to state-dependent learning.ConclusionsThus, dose is a critical determinant of the cognitive effects of psychostimulants.