Effect of dietary curcumin and dibenzoylmethane on formation of 7,12-dimethylbenz[a]anthracene-induced mammary tumors and lymphomas/leukemias in Sencar mice
Effect of dietary curcumin and dibenzoylmethane on formation of 7,12-dimethylbenz[a]anthracene-induced mammary tumors and lymphomas/leukemias in Sencar mice
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DOI：
10.1093/carcin/19.9.1697
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发表时间：
1998-09-01
期刊：
影响因子：
4.7
通讯作者：
Ho, CT
中科院分区：
文献类型：
--
作者：
Huang, MT;Lou, YR;Ho, CT
雌性Sencar小鼠（6周龄）通过口服管饲法每周一次给予1 mg 7，12-二甲基苯并[a]蒽（DMBA），持续5周。在第一剂DMBA后20周，68%的小鼠发生乳腺肿瘤（平均每只小鼠1.08个肿瘤），45%的小鼠患有淋巴瘤/白血病。在AIN 76 A饲料中加入1%二苯甲酰甲烷（DBM），从DMBA首次给药前2周开始，一直持续到实验结束，对DMBA诱发的乳腺肿瘤的多重性和发病率都有97%的抑制作用，对淋巴瘤/白血病的发病率完全抑制。相比之下，喂食2%姜黄素饮食对乳腺肿瘤的发病率几乎没有影响，淋巴瘤/白血病的发病率降低了53%。
Female Sencar mice (6 weeks old) were administered 1 mg of 7,12-dimethylbenz[a]anthracene (DMBA) by oral gavage once a week for 5 weeks. At 20 weeks after the first dose of DMBA, 68% of mice developed mammary tumors (the average 1.08 tumors per mouse) and 45% had lymphomas/leukemias. Feeding 1% dibenzoylmethane (DBM) in AIN 76A diet, starting at 2 weeks before the first dose of DMBA and continuing until the end of the experiment, inhibited both the multiplicity and incidence of DMBA-induced mammary tumor by 97%, The incidence of lymphomas/leukemias was completely inhibited by 1% DBM diet. In contrast, feeding 2% curcumin diet had little or no effect on the incidence of mammary tumors, and the incidence of lymphomas/leukemias was reduced by 53%.