A naturalistic examination of the perceived effects of cannabis on negative affect
A naturalistic examination of the perceived effects of cannabis on negative affect
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DOI：
10.1016/j.jad.2018.04.054
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发表时间：
2018-08-01
影响因子：
6.6
通讯作者：
McLaughlin, Ryan J.
中科院分区：
文献类型：
--
作者：
Cuttler, Carrie;Spradlin, Alexander;McLaughlin, Ryan J.
背景：大麻通常用于缓解负面情绪的症状。然而，很少有研究探讨大麻对日常生活中负面影响的急性影响。目前的研究提供了一个自然的帐户的感知变化的症状抑郁症，焦虑和压力作为剂量和浓度的函数Delta（9）四氢大麻酚（THC）和cannabidiol（CBD）.方法：数据从应用程序Strainprint（TM）（它提供了医疗大麻用户的手段跟踪变化的症状作为不同剂量和化学型的大麻的函数）进行了分析使用多层次建模。总共分析了11，953个跟踪会话（3，151个用于抑郁症，5，085个用于焦虑症，3，717个用于压力）。结果：医用大麻使用者认为使用大麻后抑郁症减少了50%，焦虑和压力减少了58%。两口足以降低抑郁和焦虑的评分，而10+口产生了最大的压力感知降低。高CBD（> 9.5%）/低THC（< 5.5%）大麻与抑郁评分的最大变化相关，而高CBD（> 11%）/高THC（> 26.5%）大麻产生了最大的压力变化。随着时间的推移，大麻的感知功效没有变化。然而，抑郁症的基线症状（但不是焦虑或压力）似乎是加剧跨时间/跟踪sessions.Limitations：主要的限制是样本的自我选择的性质和无法控制的期望effects.Conclusions：大麻减少了感知的症状的负面影响在短期内，但继续使用可能会加剧基线症状的抑郁症随着时间的推移。
Background: Cannabis is commonly used to alleviate symptoms of negative affect. However, a paucity of research has examined the acute effects of cannabis on negative affect in everyday life. The current study provides a naturalistic account of perceived changes in symptoms of depression, anxiety, and stress as a function of dose and concentration of Delta(9)tetrahydrocannabinol (THC) and cannabidiol (CBD).Method: Data from the app Strainprint (TM) (which provides medical cannabis users a means of tracking changes in symptoms as a function of different doses and chemotypes of cannabis) were analyzed using multilevel modeling. In total, 11,953 tracked sessions were analyzed (3,151 for depression, 5,085 for anxiety, and 3,717 for stress).Results: Medical cannabis users perceived a 50% reduction in depression and a 58% reduction in anxiety and stress following cannabis use. Two puffs were sufficient to reduce ratings of depression and anxiety, while 10+ puffs produced the greatest perceived reductions in stress. High CBD ( > 9.5%)/low THC ( < 5.5%) cannabis was associated with the largest changes in depression ratings, while high CBD ( > 11%)/high THC ( > 26.5%) cannabis produced the largest perceived changes in stress. No changes in the perceived efficacy of cannabis were detected across time. However, baseline symptoms of depression (but not anxiety or stress) appeared to be exacerbated across time/tracked sessions.Limitations: The primary limitations are the self-selected nature of the sample and the inability to control for expectancy effects.Conclusions: Cannabis reduces perceived symptoms of negative affect in the short-term, but continued use may exacerbate baseline symptoms of depression over time.