Plasma catecholamines, plasma renin activity and plasma aldosterone in tetraplegic man, horizontal and tilted.
Plasma catecholamines, plasma renin activity and plasma aldosterone in tetraplegic man, horizontal and tilted.
复制标题
四肢瘫痪患者的血浆儿茶酚胺、血浆肾素活性和血浆醛固酮，水平和倾斜。
DOI：
10.1042/cs0490291
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
W. Peart
中科院分区：
文献类型：
--
作者：
C. Mathias;C. Mathias;N. J. Christensen;J. L. Corbett;H. Frankel;T. J. Goodwins;W. Peart
1. 在四名生理性完整颈脊髓横断的受试者中，在抬头倾斜至 45 度持续 30 分钟之前、期间和之后测量血浆儿茶酚胺、血浆肾素活性、血浆醛固酮和血细胞比容。测量了 5 名正常男性志愿者仰卧位和抬头倾斜 45 度 10 分钟后的血浆儿茶酚胺含量。 2. 平视倾斜 10 分钟后，四肢瘫痪患者的血浆去甲肾上腺素升高 14%，对照组升高 115%。这些发现表明四肢瘫痪患者的交感神经活动对抬头倾斜的反应失败，这可能是由于大脑通常控制交感神经流出的通路中断所致。 3.四肢瘫痪患者的静息血浆肾素活性高于正常水平，并且与已发表的正常受试者研究相比，在抬头倾斜时上升得更快、幅度更大。肾压力感受器可能在控制肾素释放方面发挥重要作用。 4.四肢瘫痪患者血浆醛固酮较晚升高，可能与血浆肾素活性升高有关。
1. Plasma catecholamines, plasma renin activity, plasma aldosterone and haematocrit were measured in four subjects with physiologically complete cervical spinal cord transections, before, during and after head-up tilt to 45 degrees for 30 min. Plasma catecholamines were measured in five normal male volunteers in the supine position and after head-up tilt to 45 degrees for 10 min. 2. After 10 min of head-up tilt, the plasma noradrenaline rose 14% in the tetraplegic patients and 115% in the control subjects. These findings indicate a failure of sympathetic activity in response to head-up tilt in the tetraplegic patients, probably caused by interruption of pathways by which the brain normally controls sympathetic outflow. 3. In the tetraplegic patients the resting plasma renin activities were above normal, and rose more quickly and greater on head-up tilt than in published studies of normal subjects. It is likely that the renal baroreceptors are important in the control of renin release. 4. In the tetraplegic patients, there was a late rise in plasma aldosterone which was probably due to the elevation in plasma renin activity.