Exchangeability of Qsr1p, a large ribosomal subunit protein required for subunit joining, suggests a novel translational regulatory mechanism
Exchangeability of Qsr1p, a large ribosomal subunit protein required for subunit joining, suggests a novel translational regulatory mechanism
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DOI：
10.1016/s0014-5793(97)01402-6
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发表时间：
1997-12-08
期刊：
影响因子：
3.5
通讯作者：
Trumpower, BL
中科院分区：
文献类型：
--
作者：
Dick, FA;Eisinger, DP;Trumpower, BL
Qsr1p是一种60S核糖体亚基蛋白，是连接大小核糖体亚基所必需的，也是细胞质中最后组装到60S核糖体亚基上的蛋白质之一。Qsr1p与L7的发现相同，L7是一种以前被证明在细胞质中循环大的核糖体亚基的蛋白质，这表明在60S核糖体亚基上添加Qsr1p可以通过限制功能性60S亚基的供应作为一种翻译调控机制。(C)1997年欧洲生化学会联合会。
Qsr1p is a 60S ribosomal subunit protein that is necessary for joining of large and small ribosomal subunits and is also one of the last proteins assembled onto the 60S ribosomal subunit in the cytoplasm. The finding that Qsr1p is identical to L7, a protein previously shown to cycle on and off large ribosomal subunits in the cytoplasm, suggests that the addition of Qsr1p onto the 60S ribosomal subunit could be utilized as a translational regulatory mechanism by limiting the supply of functional 60S subunits. (C) 1997 Federation of European Biochemical Societies.