A Neural Switch for Active and Passive Fear
A Neural Switch for Active and Passive Fear
复制标题
DOI：
10.1016/j.neuron.2010.07.008
复制
发表时间：
2010-08-26
期刊：
影响因子：
16.2
通讯作者：
Bifone, Angelo
中科院分区：
文献类型：
--
作者：
Gozzi, Alessandro;Jain, Apar;Bifone, Angelo
杏仁核中央核（CeA）是这一结构的主要输出，在条件性恐惧的表达中起着关键作用。通过将细胞和组织特异性药物遗传学抑制与功能性磁共振成像（fMRI）相结合，我们确定了控制小鼠恐惧表达的CeA下游回路。选择性抑制CeA中的一个神经元子集导致条件性冻结行为减少，并通过fMRI观察到皮质唤醒增加。功能磁共振成像信号的相关性分析确定CeA，胆碱能前脑核团，激活的皮质结构之间的功能连接，和皮质唤醒胆碱能拮抗剂被阻断。重要的是，这些神经元的抑制将对恐惧刺激的行为反应从被动反应转变为主动反应。我们的研究结果确定了CeA的神经回路，使恐惧反应偏向被动或主动的应对策略。
The central nucleus of the amygdala (CeA) serves as a major output of this structure and plays a critical role in the expression of conditioned fear. By combining cell- and tissue-specific pharmacogenetic inhibition with functional magnetic resonance imaging (fMRI), we identified circuits downstream of CeA that control fear expression in mice. Selective inhibition of a subset of neurons in CeA led to decreased conditioned freezing behavior and increased cortical arousal as visualized by fMRI. Correlation analysis of fMRI signals identified functional connectivity between CeA, cholinergic fore-brain nuclei, and activated cortical structures, and cortical arousal was blocked by cholinergic antagonists. Importantly, inhibition of these neurons switched behavioral responses to the fear stimulus from passive to active responses. Our findings identify a neural circuit in CeA that biases fear responses toward either passive or active coping strategies.