RAPID EVOLUTION OF A UNIQUE FAMILY OF PRIMATE RIBONUCLEASE GENES
RAPID EVOLUTION OF A UNIQUE FAMILY OF PRIMATE RIBONUCLEASE GENES
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DOI：
10.1038/ng0695-219
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发表时间：
1995-06-01
期刊：
影响因子：
30.8
通讯作者：
GONZALEZ, M
中科院分区：
文献类型：
--
作者：
ROSENBERG, HF;DYER, KD;GONZALEZ, M
我们追踪了嗜酸性粒细胞衍生的神经毒素（EDN）和嗜酸性粒细胞阳离子蛋白（ECP）的快速分子进化，这两种宿主防御蛋白是哺乳动物核糖核酸酶基因家族的成员。EDN/ECP基因对来自新世界和旧世界猴子分化后发生的最近的重复事件。自复制以来，编码EDN和ECP的基因积累了非沉默突变的速率超过了灵长类动物中研究的所有其他功能编码序列，同时保留了核糖核酸酶活性所需的结构和催化成分。这些结果表明，EDN和ECP都可能对不寻常的进化限制做出反应，这促使人们重新审视它们的生理功能。
We have traced the rapid molecular evolution of eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP), two host defense proteins that are members of the mammalian ribonuclease gene family. The EDN/ECP gene pair arose from a recent duplication event that occurred after the divergence of New World and Old World monkeys. Since duplication, the genes encoding EDN and ECP have accumulated nonsilent mutations at rates exceeding those of all other functional coding sequences studied in primates, while retaining both the structural and catalytic components required for ribonuclease activity. These results suggest that both EDN and ECP may be responding to unusual evolutionary constraints, which has prompted a reexamination of their physiologic function.