Quantification of J-resolved proton spectra in two-dimensions with LCModel using GAMMA-simulated basis sets at 4 Tesla
Quantification of J-resolved proton spectra in two-dimensions with LCModel using GAMMA-simulated basis sets at 4 Tesla
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DOI：
10.1002/nbm.1390
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发表时间：
2009-08-01
影响因子：
2.9
通讯作者：
Renshaw, Perry F.
中科院分区：
文献类型：
--
作者：
Jensen, J. Eric;Licata, Stephanie C.;Renshaw, Perry F.
利用伽玛模拟的lcmodel基集，开发了一种二维、j分辨率的磁共振波谱提取方法。在该方法中，二维j分辨（2D-JPRESS）数据集被分解成一系列一维光谱，每个光谱被建模并与理论上定制的lcmodel模板拟合。代谢物水平由每个代谢物的j系列光谱的总积分得出。使用含有主要脑化学物质生理浓度的幻影进行验证。不同浓度的谷氨酸和谷氨酰胺在其可接受的体内浓度及其周围进行评估，以比较我们的方法与30 ms PRESS的准确性和精密度。我们还通过对10名健康志愿者进行一次扫描和对一名健康志愿者进行9次重复扫描，在体内评估了2D-JPRESS和30 ms PRESS在顶枕皮质内的单个体素。幻影研究表明，2D-JPRESS光谱与模拟lcmodel基础集的连续拟合提供了包括谷氨酸和谷氨酰胺在内的常见代谢物的准确浓度估计。我们使用2D-JPRESS的体内结果表明，相对于30 ms PRESS，测量谷氨酰胺和谷氨酸具有优越的重复性。这些新方法对寻求理解神经化学功能障碍的临床和研究具有明确的意义。版权所有John Wiley & Sons， Ltd. 2009
A two-dimensional, J-resolved magnetic resonance spectroscopic extraction approach was developed employing GAMMA-simulated, LCMoclel basis-sets. In this approach, a two-dimensional J-resolved (2D-JPRESS) dataset was resolved into a series of one-dimensional spectra where each spectrum was modeled and fitted with its theoretically customized LCMoclel template. Metabolite levels were derived from the total integral across the J-series of spectra for each metabolite. Phantoms containing physiologic concentrations of the major brain chemicals were used for validation. Varying concentrations of glutamate and glutamine were evaluated at and around their accepted in vivo concentrations in order to compare the accuracy and precision of our method with 30 ms PRESS. We also assessed 2D-JPRESS and 30 ms PRESS in vivo, in a single voxel within the parieto-occipital cortex by scanning ten healthy volunteers once and a single healthy volunteer over nine repeated measures. Phantom studies demonstrated that serial fitting of 2D-JPRESS spectra with simulated LCMoclel basis sets provided accurate concentration estimates for common metabolites including glutamate and glutamine. Our in vivo results using 2D-JPRESS suggested superior reproducibility in measuring glutamine and glutamate relative to 30 ms PRESS. These novel methods have clear implications for clinical and research studies seeking to understand neurochemical dysfunction. Copyright (C) 2009 John Wiley & Sons, Ltd.