Self-assembling polymer-peptide conjugates: Nanostructural tailoring
Self-assembling polymer-peptide conjugates: Nanostructural tailoring
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DOI：
10.1002/adma.200306379
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发表时间：
2004-06-04
影响因子：
29.4
通讯作者：
Messersmith, PB
中科院分区：
文献类型：
--
作者：
Collier, JH;Messersmith, PB
本文报道了一系列β-折叠纤维形成肽聚合物的合成和溶液行为。探索了几种嵌段共聚物结构，其中肽和聚合物嵌段具有各种长度和排列。一种肽聚合物，即与多分散聚（乙二醇）链缀合的11个氨基酸肽，具有形成罕见的规则、对齐和最小聚集的β折叠原纤维的能力（见图）。
The synthesis and solution behaviorof a series of β‐sheet fibril‐forming peptide–polymers is described. Several block copolymer architectures are explored, with various lengths and arrangements of the peptide and polymer blocks. One peptide–polymer, an 11‐amino acid peptide conjugated to a polydisperse poly(ethylene glycol) chain, has the ability to form uncommonly regular, aligned, and minimally aggregated β‐sheet fibrils (see Figure).