Reversal of age-associated memory impairment by rosuvastatin in rats
Reversal of age-associated memory impairment by rosuvastatin in rats
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DOI：
10.1016/j.exger.2010.02.001
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发表时间：
2010-05-01
影响因子：
3.9
通讯作者：
Schroeder, Nadja
中科院分区：
文献类型：
--
作者：
Rech, Rafael Luiz;Martins de Lima, Maria Noemia;Schroeder, Nadja
据报道，在神经退行性疾病和正常大脑老化中，大脑区域的铁水平都有所增加。我们以前已经证明了新生铁负荷会导致成年大鼠的认知功能障碍。在这里，我们评估了新生铁治疗对老年大鼠认知功能的影响。我们还观察了晚期亚慢性瑞舒伐他汀治疗对铁和老年性认知障碍的影响。大鼠在出生后12-14天给予赋形剂或10.0 mg/kg Fe2+灌胃。当动物长到23月龄时，每天给它们注射生理盐水或瑞舒伐他汀(0.2或2.0 mg/kg)，连续21天。在最后一次注射后24小时，它们接受新的物体识别训练。分别在训练后1、5和24小时进行记忆保持测试，以评估短期记忆和长期记忆。结果表明，在新生期接受铁治疗的老年动物表现出比使用铁剂治疗的老年动物更严重的记忆障碍，这表明铁强化了与年龄相关的记忆损害。瑞舒伐他汀改善与铁负荷和衰老相关的识别记忆缺陷，提供证据表明他汀类药物可能被考虑用于治疗与年龄相关的认知能力下降。(C)2010 Elsevier Inc.保留所有权利
Increased levels of Iron in brain regions have been reported in neurodegenerative disorders as well as in normal brain aging. We have previously demonstrated that neonatal iron loading induces cognitive impairment in adult rats Here, we evaluate the effects of neonatal iron treatment on cognition in aged rats We also investigated the effects of a late subchronic rosuvastatin treatment on iron- and age-induced cognitive deficits. Rats received vehicle or 10.0 mg/kg Fe2+ orally at postnatal days 12-14. When animals reached the age of 23 months, they received daily intraperitoneal injections of saline or rosuvastatin (0 2 or 2 0 mg/kg) for 21 days Twenty-four hours after the last injection, they were submitted to novel object recognition training. Retention test sessions were performed 1 5 and 24 h after training, in order to assess short-term and long-term memory, respectively Results indicated that aged animals that received iron in the neonatal period showed more severe memory deficits than vehicle-treated ones, suggesting that iron potentiates age-associated memory impairments. Rosuvastatin improved recognition memory deficits associated with iron loading and aging, providing evidence that statins may be considered for the treatment of age-associated cognitive decline. (C) 2010 Elsevier Inc. All rights reserved