The influence of pulsatile preservation in kidney transplantation from non-heart-beating donors
The influence of pulsatile preservation in kidney transplantation from non-heart-beating donors
复制标题
DOI：
10.1016/j.transproceed.2006.11.026
复制
发表时间：
2007-06-01
影响因子：
0.9
通讯作者：
Friend, P. J.
中科院分区：
文献类型：
--
作者：
Moustafellos, P.;Hadjianastassiou, V.;Friend, P. J.
与冷静态灌注（CSP）相比，持续低温搏动灌注（CHPP）可以改善心脏跳动尸体供体的早期功能。随着供体池的扩大，即非心脏跳动供体（NHBD），我们提出了使用CHPP与CSP比较保存从NHBD取出的肾移植物的初步结果。连续18例本地获取的NHBD尸体肾脏在Life Port肾脏转运体中使用UW机器灌注液CHPP保存。脉冲灌注时连续测量灌注参数。将该组与18个用CSP保存的NHBD尸体肾脏进行比较。无因制备技术或搏动灌注制备技术错误而造成器官损失。即时肾功能13例（72.2%）。在NHBD的CSP中，我们有16例移植物功能延迟（88.8%）。这些早期结果表明，使用搏动灌注来保护肾脏免受NHBD可能与改善早期预后有关。为了回答一个更重要的问题，即它是否提供了长期的改进，以证明额外的成本和复杂性是合理的，需要更长的随访时间。
Continuous hypothermic pulsatile perfusion (CHPP) may offer improved early function compared with cold static perfusion (CSP) for heart-beating cadaveric donors. With an expanding pool of donors, ie, non-heart-beating donors (NHBD), we present our preliminary results with the use of CHPP compared with CSP to preserve kidney grafts retrieved from NHBD. Eighteen consecutive locally procured cadaveric kidneys from NHBD were preserved using CHPP using UW machine perfusion solution in the Life Port kidney transporter. Perfusion parameters were measured serially during pulsatile perfusion. This group was compared with 18 NHBD cadaveric kidneys preserved with CSP. No organs were lost due to faulty technique of preparation or preparation of pulsatile perfusion. Immediate renal function was observed in 13 cases (72.2%). In CSP in NHBD, we had 16 cases with delayed graft function (88.8%). These early results show that the use of pulsatile perfusion to preserve kidneys from NHBD may be associated with improved early outcomes. Longer follow-up is required to answer the more important question as to whether it offers long-term improvements that justify the extra cost and complexity.