Expression of AID in malignant melanoma with BRAFV600E mutation
Expression of AID in malignant melanoma with BRAFV600E mutation
复制标题
DOI：
10.1111/exd.12402
复制
发表时间：
2014-05
影响因子：
3.6
通讯作者：
Risa Okura;Haruna Yoshioka;M. Yoshioka;Kana Hiromasa;D. Nishio;Motonobu Nakamura
中科院分区：
文献类型：
--
作者：
Risa Okura;Haruna Yoshioka;M. Yoshioka;Kana Hiromasa;D. Nishio;Motonobu Nakamura
BRAF激活体细胞突变通常存在于恶性黑色素瘤中。体细胞BRAF突变诱导的潜在分子机制仍不清楚。活化诱导的胞苷脱氨酶（AID）是胞苷脱氨酶家族的一员，APOBEC3B诱导体细胞突变，最近已表明参与几种癌症的病理机制。本研究旨在探讨AID和APOBEC3B在BRAF突变恶性黑色素瘤中的表达水平。免疫组化结果显示，10例AID高表达的恶性黑色素瘤中，9例存在BRAFV600E突变。其中8例发生多器官或多淋巴结转移。尽管患者样本量很小，但结果表明黑色素瘤中AID表达和BRAF突变之间可能存在关联。
BRAF‐activating somatic mutations often exist in malignant melanoma. The underlying molecular mechanism of somatic BRAF mutation inductions remained to be clear. Activation‐induced cytidine deaminase (AID), a member of a cytidine deaminase family, and APOBEC3B induce somatic mutations and recently have been indicated to be involved in the pathomechanism of several kinds of cancers. The aim of this study was to explore the expression level of AID and APOBEC3B in BRAF‐mutation‐ containing malignant melanoma. Immunohistochemical study demonstrated that 9 of 10 malignant melanomas with high AID expression had BRAFV600E mutation. Eight of them developed multiorgan metastases or multiple lymph node metastases afterwards. Although the size of the patient panel was small, the results indicate that there might be an association between AID expression and BRAF mutation in melanoma.