Timing of postexercise carbohydrate-protein supplementation: roles of gastrointestinal blood flow and mucosal cell damage on gastric emptying in humans
Timing of postexercise carbohydrate-protein supplementation: roles of gastrointestinal blood flow and mucosal cell damage on gastric emptying in humans
复制标题
DOI：
10.1152/japplphysiol.00247.2017
复制
发表时间：
2017-09-01
影响因子：
3.3
通讯作者：
Fukuba, Yoshiyuki
中科院分区：
文献类型：
--
作者：
Kashima, Hideaki;Harada, Nao;Fukuba, Yoshiyuki
众所周知，运动后立即摄入蛋白质可以极大地刺激运动后恢复期肌肉蛋白质的合成。然而，剧烈运动后，胃肠道(GI)粘膜经常因器官/组织灌流不足而受损，可能导致GI功能受损(例如，胃排空；GE)。这项研究的目的是检查胃肠道血流对GE率的影响。8名健康青年受试者进行了30min的间歇性超极量自行车运动，其中20名S进行120%(V)的O2Peak运动，随后40名S进行20W运动。受试者在一次试验(PE-5)运动后5min或在另一次试验(PE-30)运动后30min分别摄入含有碳水化合物和蛋白质的营养饮料300ml。在对照试验(CON)中，受试者在没有运动的情况下摄入相同的饮料。超声检测腹主动脉血流量(CABF)、肠系膜上动脉血流量(SMABF)及GE率。PE-5组饮酒前CABF较基础值显著降低，而PE-30组CABF恢复至基础水平。在摄入PE-5饮料后，CABF没有改变，但在PE-30和Conn中显著增加。SMABF在PE-5中增加的时间明显晚于PE-30和Conn。PE-5的GE率始终低于PE-30和Conn。总之，运动后的CABF反应似乎调节了随后的GE率和SMABF反应。值得注意的是，碳水化合物-蛋白质饮料在运动后5分钟(即腹主动脉血流严重减少)或30分钟(即已经恢复的CABF)被摄入。在运动后5min试验中，胃排空(GE)率和肠系膜上动脉血流(SMABF)反应均慢于运动后30min试验。GE率和SMABF反应可根据运动后CABF反应而改变。
It is well known that protein ingestion immediately after exercise greatly stimulates muscle protein synthesis during the postexercise recovery phase. However, immediately after strenuous exercise, the gastrointestinal (GI) mucosa is frequently injured by hypoperfusion in the organ/tissue, possibly resulting in impaired GI function (e.g., gastric emptying; GE). The aim of this study was to examine the effect of GI blood flow on the GE rate. Eight healthy young subjects performed an intermittent supra-maximal cycling exercise for 30 min, which consisted of a 120% (V) over dot(O2peak) for 20 s, followed by 20 W for 40 s. The subjects ingested 300 ml of a nutrient drink containing carbohydrate-protein at either 5 min postexercise in one trial (PE-5) or 30 min postexercise in another trial (PE-30). In the control trial (Con), the subjects ingested the same drink without exercise. The celiac artery blood flow (CABF) and superior mesenteric artery blood flow (SMABF) and GE rate were assessed by ultrasonography. Before drink ingestion in PE-5, CABF significantly decreased from baseline, whereas in PE-30, it returned to baseline. Following drink ingestion in PE-5, CABF did not change from baseline, but it significantly increased in PE-30 and Con. SMABF increased significantly later in PE-5 than in PE-30 and Con. The GE rate was consistently slower in PE-5 than in PE-30 and Con. In conclusion, the CABF response after exercise seems to modulate the subsequent GE rate and SMABF response.NEW & NOTEWORTHY A carbohydrate-protein drink was ingested at either 5 min (i.e., profoundly decreased celiac artery blood flow; CABF) or 30 min (i.e., already recovered CABF) postexercise. In the 5-min postexercise trial, the gastric emptying (GE) rate and superior mesenteric artery blood flow (SMABF) response were slower than those in the 30-min postexercise trial. The GE rate and SMABF response may be altered depending on the postexercise CABF response.