DOCUMENTATION OF HYPERGLUCAGONEMIA THROUGHOUT THE DAY IN NONOBESE AND OBESE PATIENTS WITH NONINSULIN-DEPENDENT DIABETES-MELLITUS
DOCUMENTATION OF HYPERGLUCAGONEMIA THROUGHOUT THE DAY IN NONOBESE AND OBESE PATIENTS WITH NONINSULIN-DEPENDENT DIABETES-MELLITUS
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DOI：
10.1210/jcem-64-1-106
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发表时间：
1987-01-01
影响因子：
5.8
通讯作者：
JASPAN, JB
中科院分区：
文献类型：
--
作者：
REAVEN, GM;CHEN, YDI;JASPAN, JB
在正常人和非胰岛素依赖型糖尿病（NIDDM）患者中测定8小时内血糖、胰岛素、FFA、胰高血糖素和GH浓度。在0800 h（每日热量的20%）和中午（每日热量的40%）进食，从0800 - 1600 h每小时进行测量。无论肥胖与否，NIDDM患者全天血糖、胰岛素和FFA浓度均高于正常值（双向方差分析）。此外，非肥胖和肥胖NIDDM患者一天的血浆胰高血糖素浓度也高于正常（双向方差分析）。此外，发现0800 - 1600 h的总血浆胰高血糖素反应与总血浆葡萄糖（r = 0.57; P <0.001）和FFA（r = 0.30; P <0.06）反应之间存在直接关系。与此相反，血浆GH水平没有增加与NIDDM患者。这些数据表明，周围的血浆浓度的葡萄糖和FFA是较高的NIDDM患者，尽管事实上，共存的血浆胰岛素水平等于或高于正常。NIDDM患者全天血浆胰高血糖素水平升高可能与其血糖和FFA浓度升高有关。
Plasma glucose, insulin, FFA, glucagon, and GH concentrations were measured over an 8-h period in normal subjects and patients with noninsulin-dependent diabetes mellitus (NIDDM). Meals were consumed at 0800 h (20% of daily calories) and noon (40% of daily calories), and measurements were made hourly from 0800-1600 h. Day-long plasma glucose, insulin, and FFA concentrations were higher than normal (by two-way analysis of variance) in patients with NIDDM, whether obese or nonobese. In addition, day-long plasma glucagon concentrations were also higher than normal (by two-way analysis of variance) in both nonobese and obese patients with NIDDM. Furthermore, direct relationships were found between the total plasma glucagon response from 0800-1600 h and total plasma glucose (r=0.57; P < 0.001) and FFA (r=030; P < 0.06) responses. In contrast, plasma GH levels were not increased in patients with NIDDM. These data demonstrate that ambient plasma concentrations of both glucose and FFA are higher in patients with NIDDM, despite the fact that coexisting plasma insulin levels are equal to or higher than normal. The higher day-long plasma glucagon levels in patients with NIDDM may contribute to their higher plasma glucose and FFA concentrations.