Genetic variants in adiponectin and blood pressure responses to dietary sodium or potassium interventions: a family-based association study.
Genetic variants in adiponectin and blood pressure responses to dietary sodium or potassium interventions: a family-based association study.
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脂联素的遗传变异和血压对饮食钠或钾干预的反应：一项基于家庭的关联研究
DOI：
10.1038/jhh.2016.5
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发表时间：
2016-09
影响因子：
2.7
通讯作者：
Mu JJ
中科院分区：
文献类型：
--
作者：
Chu C;Wang Y;Ren KY;Yan DY;Guo TS;Zheng WL;Yuan ZY;Mu JJ
以往的研究表明，遗传因素可能在血压（BP）对膳食盐或钾摄入量的反应中起重要作用。本研究的目的是评估脂联素基因的常见遗传变异与控制饮食钠或钾干预的血压反应之间的关联。受试者（n= 334）来自中国北方农村地区的124个家庭。经过3天的基线观察后，参与者连续维持7天的低钠饮食（NaCl，3 g/天;或钠，51.3 mmol/天），随后7天高钠饮食（NaCl，18 g/天;或钠，307.8 mmol/天）和7天高钠加钾补充干预（KCl，每天4.5 g;或钾，每天60 mmol）。共选择脂联素基因的7个单核苷酸多态性（SNPs）作为研究位点。调整多重检验后，脂联素SNP rs 16861205与低盐干预的舒张压（DBP）反应以及高盐干预的DBP和平均动脉压（MAP）反应显著相关（分别为P= 0.028，0.023和0.027）。SNP rs 822394与DBP和MAP对低盐干预的反应以及DBP对高盐干预的反应相关（P分别为0.023、0.030和0.033）。同时，SNP rs 16861194与补钾干预后收缩压的变化有显著相关性（P= 0.026）。此外，SNP rs 822394与校正多重测试后的基础DBP显著相关（P= 0.033）。我们的研究表明脂联素基因的遗传多态性与血压对膳食钠和钾摄入的反应显著相关。
Previous studies have shown that genetic factors might have an important role in blood pressure (BP) responses to dietary salt or potassium intake. The aim of this study was to assess the association of common genetic variants of the adiponectin gene with BP responses to controlled dietary sodium or potassium interventions. Subjects (n= 334) from 124 families in rural areas of Northern China were recruited. After a 3-day baseline observation, participants sequentially maintained a 7-day low-sodium diet (NaCl, 3 g per day; or sodium, 51.3 mmol per day), followed by a 7-day high-sodium diet (NaCl, 18 g per day; or sodium, 307.8 mmol per day) and a 7-day high-sodium plus potassium supplementation intervention (KCl, 4.5 g per day; or potassium, 60 mmol per day). A total of seven single nucleotide polymorphisms (SNPs) in the adiponectin gene were selected as the study sites. After adjustment for multiple testing, the adiponectin SNP rs16861205 was significantly associated with the diastolic BP (DBP) response to low-salt intervention, and the DBP and mean arterial pressure (MAP) responses to high-salt intervention (P= 0.028, 0.023 and 0.027, respectively). SNP rs822394 was associated with the DBP and MAP responses to low-salt intervention and the DBP response to high-salt intervention (P= 0.023, 0.030 and 0.033 respectively). Meanwhile, significant association also existed between SNP rs16861194 and the systolic BP response to potassium supplementation intervention (P= 0.026). In addition, SNP rs822394 was significantly associated with basal DBP after adjustment for multiple testing (P= 0.033). Our study indicated that the genetic polymorphisms in the adiponectin gene are significantly associated with BP responses to dietary sodium and potassium intake.