Genetic causal attributions for weight status and weight loss during a behavioral weight gain prevention intervention.
Genetic causal attributions for weight status and weight loss during a behavioral weight gain prevention intervention.
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DOI：
10.1038/gim.2015.109
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发表时间：
2016-05
期刊：
影响因子：
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通讯作者：
Bennett GG
中科院分区：
文献类型：
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作者：
McVay MA;Steinberg DM;Askew S;Kaphingst KA;Bennett GG
新出现的证据表明，将一个人的体重归因于遗传可能有助于采取肥胖行为。我们研究了在体重增加预防干预期间，体重相关的遗传因素是否与体重变化相关。参与者（n=185）来自一项针对年龄在25-44岁、BMI为25.0-34.9kg/m2的黑人女性的数字健康体重增加预防干预的随机临床试验。在基线和12个月时测量体重相关的遗传属性（体重状态属性和体重减轻属性）。在干预参与者中，体重减轻的高遗传归因与12个月（-2.7 kg vs 0.5 kg）和18个月（-3.0 kg vs 0.9 kg）的体重减轻有关。在常规护理参与者中，体重状况的高遗传归因与18个月的体重增加（2.9 kg vs 0.3 kg）相关。干预降低了12个月时体重减轻的高遗传归因的可能性（p=0.05）。遗传归因可能性的变化与12个月内的体重变化无关。遗传因素对体重的影响对于那些参加和没有参加干预的人是不同的。然而，体重增加预防干预可能会减少体重减轻的遗传归因。
Emerging evidence suggests that attributing one’s weight to genetics may contribute to the adoption of obesogenic behaviors. We examined if weight-related genetic attributions were associated with weight change during a weight gain prevention intervention. Participants (n=185) were from a randomized clinical trial of a digital health weight gain prevention intervention for Black women age 25–44 with BMI 25.0–34.9kg/m2. Weight-related genetic attributions (weight status attribution and weight loss attributions) were measured at baseline and 12 months. Among intervention participants, high genetic attribution for weight loss was associated with greater weight loss at 12 months (−2.7 kg vs 0.5 kg) and 18 months (−3.0 kg vs 0.9 kg). Among usual care participants, high genetic attribution for weight status was associated with greater 18-month weight gain (2.9 kg vs 0.3 kg). The intervention reduced likelihood of high genetic attribution for weight loss at 12 months (p=0.05). Change in likelihood of genetic attribution was not associated with weight change over 12 months. Impact of genetic attributions on weight differs for those enrolled and not enrolled in an intervention. However, weight gain prevention intervention may reduce genetic attribution for weight loss.