[Bone changes with long term administration of low dose 1-34 human PTH on adult beagles].
[Bone changes with long term administration of low dose 1-34 human PTH on adult beagles].
复制标题
[长期给予成年比格犬低剂量1-34人PTH引起的骨骼变化]。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
J. Inoue
中科院分区：
文献类型：
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作者：
J. Inoue
有研究表明，长期服用低剂量甲状旁腺激素可能对骨骼产生合成代谢作用。研究了近生理剂量注射甲状旁腺激素对正常成年小猎犬骨小梁和骨皮质的影响。12只18个月大的雄性比格犬按体重分为4组。第1组作为对照组皮下注射生理盐水1 ml，第2、3、4组分别皮下注射合成1-34人甲状旁腺激素1.25、5.0、20.0单位/kg/天，连续15周。然后，在接下来的8周内，停止给药和给药。双骨标记后，在给药前后和停药后分别行髂骨和肋骨活检。通过血液化学、激素分析和骨组织形态测定来评价其效果。血清钙、磷、甲状旁腺素、降钙素和1,25 (OH)2维生素无明显变化。D水平和A1-P活动有一些例外。骨小梁的骨组织形态测量结果显示，骨形成面、活性形成面、矿物附着率、标记面和骨形成率均有显著升高，且有统计学意义。另一方面，骨吸收率和其他一些吸收参数明显升高，但骨小梁体积没有明显增加。在皮质骨中，骨动力学基本等同于小梁骨。但随着骨周转率的增加，皮质孔隙率增加。停药后，骨周转率下降，皮质孔隙率恢复正常。从这些结果可以推测甲状旁腺激素在激活骨骼的低重塑方面是有效的。
It has been suggested that prolonged administration of low dose PTH could exert an anabolic effect on the bone. The effects of near-physiological dose of PTH injection on trabecular and cortical bones were studied in normal young adult beagles. Twelve 18 month-old male beagle dogs were equally divided into 4 groups by body weight. The 1st group serving as the control was subcutaneously injected with 1 ml of normal saline, and the 2nd, the 3rd and the 4th groups were also subcutaneously injected with 1.25, 5.0, 20.0 unit/kg/day of synthetic 1-34 human PTH respectively everyday for 15 weeks. Then, over the following 8 weeks, administration of all vehicle and drugs was withdrawn. After double bone labeling, iliac bone and rib biopsies were taken before and after the drug administration and after the withdrawal. The effects were evaluated with blood chemical and hormonal analysis and bone histomorphometry. No significant changes were noted in serum Ca, P, PTH, calcitonin and 1,25 (OH)2 vit.D levels and A1-P activities with some exceptions. Bone histomorphometry on trabecular bone showed remarkable and statistically significant elevation of formation surface, active formation surface, mineral appositional rate, labeled surface and bone formation rate. On the other hand, bone resorption rate and some other resorption parameters showed a significant elevation but trabecular bone volume showed no significant increase. In cortical bone, the bone dynamics were essentially equal to trabecular bone. But by the increase of bone turnover rate, cortical porosity rate increased. After withdrawal of drug administration, the bone turnover rate went down and a rate of cortical porosity returned to normal level. From these results it was postulated that PTH was effective in activating low remodeling of the skeleton.