Sweetener preference of C57BL/6ByJ and 129P3/J mice
Sweetener preference of C57BL/6ByJ and 129P3/J mice
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DOI：
10.1093/chemse/26.7.905
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发表时间：
2001-09-01
期刊：
影响因子：
3.5
通讯作者：
Beauchamp, GK
中科院分区：
文献类型：
--
作者：
Bachmanov, AA;Tordoff, MG;Beauchamp, GK
先前的研究表明，C57BL/6ByJ (B6) 和 129P3/J (129) 近交系小鼠对几种甜味剂的味觉反应存在很大差异。本研究的目的是比较 B6 和 129 小鼠对更多种甜味剂的行为反应。使用两瓶水偏好测试测试了 17 种甜味剂。应变差异的三种主要模式是明显的。首先，两种品系均偏好蔗糖、麦芽糖、糖精、安赛蜜、三氯蔗糖和 SC-45647，但 B6 小鼠的偏好阈值较低，溶液摄入量较高。其次，B6 小鼠高度偏爱 D-苯丙氨酸、D-色氨酸、L-脯氨酸和甘氨酸，但 129 小鼠则不然。第三，甘草酸、新橙皮苷二氢查耳酮、奇异果甜蛋白和甜蜜素在任一菌株中都没有引起强烈的偏好。阿斯巴甜对所有 129 只小鼠和一些 B6 小鼠呈中性，但其他 B6 小鼠强烈偏爱它。因此，与 129 只小鼠相比，B6 小鼠对糖、甜味氨基酸和几种但并非全部无热量甜味剂有更高的偏好。甘草酸、新橙皮苷、索马甜和甜蜜素对于 B6 或 129 小鼠来说不好吃。
Previous studies have shown large differences in taste responses to several sweeteners between mice of the C57BL/6ByJ (B6) and 129P3/J (129) inbred strains. The goal of this study was to compare behavioral responses of B6 and 129 mice to a wider variety of sweeteners. Seventeen sweeteners were tested using two-bottle preference tests with water. Three main patterns of strain differences were evident. First, sucrose, maltose, saccharin, acesulfame-K, sucralose and SC-45647 were preferred by both strains, but the B6 mice had lower preference thresholds and higher solution intakes. Second, the amino acids D-phenylalanine, D-tryptophan, L-proline and glycine were highly preferred by B6 mice, but not by 129 mice. Third, glycyrrhizic acid, neohesperidin dihydrochalcone, thaumatin and cyclamate did not evoke strong preferences in either strain. Aspartame was neutral to all 129 and some B6 mice, but other B6 mice strongly preferred it. Thus, compared with the 129 mice the B6 mice had higher preferences for sugars, sweet tasting amino acids and several but not all non-caloric sweeteners. Glycyrrhizic acid, neohesperidin, thaumatin and cyclamate are not palatable to B6 or 129 mice.