A comprehensive description of muscle symptoms associated with lipid-lowering drugs
A comprehensive description of muscle symptoms associated with lipid-lowering drugs
复制标题
DOI：
10.1023/b:card.0000015861.26111.ab
复制
发表时间：
2003-09-01
影响因子：
3.4
通讯作者：
Turpin, E
中科院分区：
文献类型：
--
作者：
Franc, S;Dejager, S;Turpin, E
从肌痛到横纹肌溶解的一系列疾病是降脂治疗（LLT）的典型副作用。虽然肌病引起了相当大的兴趣，但对轻度肌肉骨骼症状的评估却很差。目的：报道LLT的肌肉副作用，特别关注被忽视的轻微副作用。方法：高脂血症患者在LLT下，并抱怨肌肉症状完成自我管理问卷。在La Pitie医院心血管预防科接受LLT治疗的815名成年高脂血症患者中，有165名患者回答说他们经历过或曾经经历过肌肉症状，他们认为这些症状是LLT引起的。其中133人完成并上交了一份自我管理的问卷。结果：揭示了症状与LLT之间的明确时间顺序联系，要么是因为它们在药物开始后不久出现，要么是因为药物停药后改善。虽然抽筋和僵硬是最常见的症状，但与肌腱炎相关的疼痛却令人惊讶地普遍，几乎有一半的病例报告。疼痛常为弥漫性，集中于某一特定部位，以下肢为主。39%的患者使用镇痛药缓解疼痛。出乎意料的是，大多数患者报告在休息和躺姿时疼痛。在一些病例中，发现了LLT下疼痛的家族史。结论：在一部分患者中，这些轻微症状对日常活动的影响可能不可忽视。易患低度肌病的遗传背景的作用和重要性值得进一步研究。
A spectrum of disease from myalgia to rhabdomyolysis exists as classic side-effect of lipid-lowering treatment (LLT). While myopathy has generated considerable interest, mild musculo-skeletal symptoms are poorly assessed.Objective: To report on the muscular side-effects of LLT with a particular focus on the overlooked milder ones.Methods: Hyperlipidemic patients under LLT and complaining of muscle symptoms were asked to complete a self administered questionnaire. Among the 815 adult hyperlipidemic patients under LLT and referred to the cardiovascular prevention unit of La Pitie Hospital, 165 patients answered that they experienced, or had experienced, muscle symptoms which they attributed to the LLT. One hundred and thirty three of these completed and returned a self-administered questionnaire.Results: A clear chronological link between symptoms and the LLT was revealed, either because they appeared soon after drug initiation or because of an improvement after drug withdrawal.While cramps and stiffness were the most frequent symptoms, tendonitis-associated pain was surprisingly common, reported in almost half the cases. Pain was often diffuse with a focus on a given location, mainly lower limbs. 39% of patients had used analgesics for pain relief. Unpredictably, a majority of patients reported pain during rest and the lying position. In a number of cases, a family history of pain under LLT was revealed.Conclusion: The impact of these mild symptoms on daily activities might not be negligible in a subset of patients. The role and importance of a genetic background predisposing to low-grade myopathy deserves further investigation.