Familial aggregation of blood pressure and weight in adoptive families. II. Estimation of the relative contributions of genetic and common environmental factors to blood pressure correlations between family members.
Familial aggregation of blood pressure and weight in adoptive families. II. Estimation of the relative contributions of genetic and common environmental factors to blood pressure correlations between family members.
复制标题
收养家庭血压和体重的家族聚集。
DOI：
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发表时间：
1979
影响因子：
5
通讯作者：
J. Mongeau
中科院分区：
文献类型：
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作者：
J. Annest;C. Sing;P. Biron;J. Mongeau
对血压（BP）的家族聚集性进行了分析，以估计基因和家庭环境在确定生物学相关家庭成员之间表型相似性中的作用。用于此分析的生物模型将家庭成员之间的相关性参数化为遗传和环境变异性在代内和代间共享的贡献。对模型中不同参数的假设检验表明，与收缩压相比，共享的环境解释了舒张压的父母-亲生子女和全同胞相关性的更大比例。对于舒张压，家庭中的儿童除了与父母共享的影响外，还共享共同环境的影响。家庭成员之间的相似程度依赖于两代人之间共有的环境因素的影响，这不能用个体之间同居时间长短的差异来解释。
An analysis of the familial aggregation of blood pressure (BP) was conducted to provide estimates of the role of genes and household environment in determining the phenotypic resemblance between biologically related family members. The biological model used for this analysis parameterizes the correlations between family members into the contributions of genetic and environmental variability shared within and across generations. Hypothesis testing about different parameters in the model suggests that shared environment explains larger fractions of the parent-natural child and the full sib correlations for diastolic BP than for systolic BP. For diastolic BP, children in a household share the effects of common environment in addition to the effects which they share with their parents. Dependence of the degree of resemblance between household members on the effects of environmental factors shared within and a-ross generations is not explained by the variability of length of cohabitation among individuals.