Effects of elevated serum prolactin on bone mineral density and bone metabolism in female patients with schizophrenia: A prospective study
Effects of elevated serum prolactin on bone mineral density and bone metabolism in female patients with schizophrenia: A prospective study
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DOI：
10.1176/appi.ajp.160.9.1618
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发表时间：
2003-09-01
影响因子：
17.7
通讯作者：
Josiassen, RC
中科院分区：
文献类型：
--
作者：
Abraham, G;Paing, WW;Josiassen, RC
目的：本研究的目的是前瞻性地研究持续的“高”和“低”血清催乳素水平对骨密度和外周骨代谢标志物的差异影响。方法：采用双能X线骨密度仪测量骨密度。外周骨形成和骨吸收的标志物被用来衡量14名白人女性精神分裂症患者的骨代谢与利培酮或奥氮平单药治疗超过12 months.Results：方差分析未能显示催乳素升高和骨矿物质丢失随着时间的推移之间的关联。然而，较高的骨形成和吸收率被认为是在那些高催乳素level.Conclusions：结果未能表明，催乳素升高加速骨密度丢失。然而，持续的高催乳素血症确实对骨代谢率有影响。也许在代谢过程变得不耦合之前，更长时间内更高的催乳素水平是必要的，从而导致骨密度损失。
Objective: This study was designed to prospectively examine differential effects of sustained "high" and "low" serum prolactin levels on bone mineral density and peripheral markers of bone metabolism.Method: A dual-energy X-ray absorptiometer was used to measure bone mineral density. Peripheral markers of bone formation and resorption were used to measure bone metabolism in 14 Caucasian female patients with schizophrenia treated with risperidone or olanzapine monotherapy over 12 months.Results: Analyses of variance failed to show an association between elevated prolactin and bone mineral loss over time. However, higher rates of bone formation and resorption were seen in those with high prolactin levels.Conclusions: The results failed to show that elevated prolactin accelerates bone mineral density loss. However, sustained hyperprolactinemia did have an impact on the rate of bone metabolism. Perhaps higher prolactin levels over longer time periods are necessary before the metabolic processes become uncoupled, leading to bone mineral density loss.