Identification and characterization of an insular auditory field in mice
Identification and characterization of an insular auditory field in mice
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DOI：
10.1111/j.1460-9568.2011.07926.x
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发表时间：
2011-12
影响因子：
3.4
通讯作者：
Hiroyuki Sawatari;Yoshihide Tanaka;M. Takemoto;M. Nishimura;K. Hasegawa;K. Saitoh;Wen-Jie Song
中科院分区：
文献类型：
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作者：
Hiroyuki Sawatari;Yoshihide Tanaka;M. Takemoto;M. Nishimura;K. Hasegawa;K. Saitoh;Wen-Jie Song
我们使用基于电压敏感染料的成像技术来识别和表征小鼠的岛叶听觉场（IAF）。先前的研究已经确定了小鼠听觉皮层的五个听觉区域，包括初级听觉区域和前听觉区域。本研究通过检查每个区域的音调证实了初级区域和前听觉区域的存在。此外，我们还发现了一个先前未报道的 IAF 位于已知听觉场的喙部。 IAF 中的纯音诱发反应在较低频率的所有听觉场中表现出最短的延迟。在所有受检动物的 IAF 中均观察到从前腹侧到背尾侧的频率梯度。 IAF 中的响应幅度和响应持续时间均不随频率变化，但激活面积随着音调频率的降低而显着增加。总而言之，目前的结果表明小鼠体内存在 IAF，其特征表明其在快速检测传入声音的低频分量中发挥作用。
We used voltage‐sensitive‐dye‐based imaging techniques to identify and characterize the insular auditory field (IAF) in mice. Previous research has identified five auditory fields in the mouse auditory cortex, including the primary field and the anterior auditory field. This study confirmed the existence of the primary field and anterior auditory field by examining the tonotopy in each field. Further, we identified a previously unreported IAF located rostral to known auditory fields. Pure tone evoked responses in the IAF exhibited the shortest latency among all auditory fields at lower frequencies. A rostroventral to dorsocaudal frequency gradient was consistently observed in the IAF in all animals examined. Neither the response amplitude nor the response duration changed with frequency in the IAF, but the area of activation exhibited a significant increase with decreasing tone frequency. Taken together, the current results indicate the existence of an IAF in mice, with characteristics suggesting a role in the rapid detection of lower frequency components of incoming sound.