Lipoprotein(a) and lipoprotein profile in healthy centenarians: a reappraisal of vascular risk factors
Lipoprotein(a) and lipoprotein profile in healthy centenarians: a reappraisal of vascular risk factors
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DOI：
10.1096/fasebj.12.6.433
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发表时间：
1998-04-01
期刊：
影响因子：
4.8
通讯作者：
Franceschi, C
中科院分区：
文献类型：
--
作者：
Baggio, G;Donazzan, S;Franceschi, C
在这项研究中，我们评估了广泛接受的动脉粥样硬化性血管疾病的危险因素，例如脂蛋白（a）[Lp（a）]（一种严格遗传控制下的富含胆固醇的脂蛋白）以及其他脂质参数是否随着年龄而变化。老年人（尤其是高龄老年人）的血液水平变化和 Lp(a) 的病理生理作用尚不清楚。因此，我们测量了 75 名健康百岁老人、114 名随机选择的 65 岁以下受试者、73 名随机选择的老年人和 30 名健康老年人的血清中的 Lp(a) 水平以及总胆固醇、低密度脂蛋白和高密度脂蛋白胆固醇 (CT) 以及甘油三酯 (TG)。结果显示，Lp(a) 血清水平不因年龄组而异，包括百岁老人。值得注意的是，四分之一的百岁老人的 Lp(a) 血清水平较高，尽管他们从未患过动脉粥样硬化相关疾病。与年轻人和老年人不同的是，Lp(a)血清水平较高的百岁老人血浆中促炎细胞因子IL-6的浓度也较高，这表明Lp(a)血清水平的遗传控制可能会随着年龄的增长而减弱，而慢性亚临床炎症过程等环境因素可能发挥作用。我们还发现，大多数百岁老人都有一个矛盾的特征，即低 HDL-CT 和相对较高的 TG 水平，这两者一起被认为是冠心病的强大危险因素。总的来说，这些数据支持这样的假设：生理衰老过程中脂质代谢会发生连续而复杂的重塑，可能有助于成功衰老。
In this study we assessed whether widely accepted risk factors for atherosclerotic vascular diseases such as lipoprotein(a) [Lp(a)], a cholesterol-rich lipoprotein under strict genetical control, and other lipid parameters change with age. The variations of blood levels and the pathophysiological role of Lp(a) in old people, and particularly in the oldest old, are unknown. Accordingly, we measured Lp(a) levels as well as total, LDL, and HDL cholesterol (CT), and triglycerides (TG) in sera from 75 healthy centenarians, 114 randomly selected subjects under 65 years, 73 randomly selected elderly people, and 30 healthy selected elderly people. The results showed that Lp(a) serum levels did not vary by age group, including centenarians. Remarkably, one-quarter of the centenarians had high Lp(a) serum levels even though they never suffered from atherosclerosis-related diseases. At variance with young and aged people, centenarians with high Lp(a) serum levels also had high plasma concentrations of the proinflammatory cytokine IL-6, suggesting that genetic control of the Lp(a) serum level may attenuate with age and that environmental factors such as chronic subclinical inflammatory processes may play a role. We also showed that most centenarians are paradoxically characterized by low HDL-CT and relatively high TG levels, which together are considered to be strong risk factors for coronary heart disease. On the whole, these data support the hypothesis that a continuous and complex reshaping of lipid metabolism occurs in physiological aging, likely contributing to successful aging.