Dissociating anticipation from perception: Acute pain activates default mode network
Dissociating anticipation from perception: Acute pain activates default mode network
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DOI：
10.1002/hbm.22062
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发表时间：
2013-09-01
影响因子：
4.8
通讯作者：
Beydon, Laurent
中科院分区：
文献类型：
--
作者：
Ter Minassian, Aram;Ricalens, Emmanuel;Beydon, Laurent
很少有研究探讨急性疼痛对注意网络和默认模式网络的影响。此外，这些研究传达了相互矛盾的结果，似乎是由设计引起的。为了重新评估这一问题，我们研究了20名健康受试者，在进行痛苦的电击时进行功能磁共振成像。该设计被故意构造成将休息、预期和疼痛感知分开。我们发现，默认模式网络活动对疼痛的反应是双相的。在预期过程中，当背侧注意网络被激活时，它就被关闭了。在疼痛感知过程中，默认模式网络被激活，注意力网络也被激活。左侧后梭状回表现出与默认模式网络相同的动力学，其活动与受试者的疼痛强度评级呈负相关。联合前扣带皮层似乎在这些共激活中发挥了关键作用。这些结果与文献中的数据一致，表明增强的疼痛感知导致更大的默认模式网络活动，默认模式网络和背侧注意网络之间的联系在慢性疼痛患者中消失。《脑地图》34：2228-2243，2013年。(c)2012 Wiley Periodicals，Inc.
Few studies have explored the effect of acute pain on attentional networks and on the default mode network. Moreover, these studies convey conflicting results, seemingly caused by design. To reassess this issue, we studied 20 healthy subjects with functional magnetic resonance imaging while delivering painful electric shocks. The design was purposely constructed to separate rest, anticipation, and pain perception. We found that default mode network activity in response to pain was biphasic. It deactivated during anticipation when the dorsal attentional network was activated. During pain perception, the default mode network was activated, as were attentional networks. The left posterior fusiform gyrus showed the same dynamics as the default mode network, and its activity was negatively correlated to the subject's pain intensity rating. The associative pregenual anterior cingulate cortex seemed to play a key role in these coactivations. These results concur with data from the literature showing that enhanced pain perception results in greater default mode network activity and that the anticorrelation between the default mode network and the dorsal attentional network disappears in chronic pain patients. Hum Brain Mapp 34:2228-2243, 2013. (c) 2012 Wiley Periodicals, Inc.