DETERMINATION OF CARDIAC OUTPUT BY EQUATING VENOUS RETURN CURVES WITH CARDIAC RESPONSE CURVES
DETERMINATION OF CARDIAC OUTPUT BY EQUATING VENOUS RETURN CURVES WITH CARDIAC RESPONSE CURVES
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DOI：
10.1152/physrev.1955.35.1.123
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发表时间：
1955-01-01
影响因子：
33.6
通讯作者：
GUYTON, AC
中科院分区：
文献类型：
--
作者：
GUYTON, AC
讨论了右房压升高时影响心输出量增加的因素。另一方面，对影响静脉返心的不太常见的因素进行了较详细的讨论，指出右心房压不利于血液返心，而平均循环充盈压促进血液返心。平均循环充盈压与右心房压之差表示静脉流量的压力梯度。发生在右心房附近的外周阻力变化对静脉回流的影响很大，而发生在离右心房越来越远的外周阻力变化对静脉回流的影响越来越小。影响静脉回流的各种因素用公式表示。它说明了如何静脉回流曲线可以等同于心脏反应曲线；通过使这些曲线相等，心输出量和右房压同时确定。
The factors which affect the ability of the heart to respond with increasing cardiac output as the right atrial pressure rises were discussed. On the other hand, the less popularized factors which affect venous return of blood to the heart were discussed at greater length, it pointing out that right atrial pressure opposes return of blood to the heart, whereas the mean circulatory filling pressure promotes return of blood to the heart. The difference between mean circulatory filling pressure and right atrial pressure represents a pressure gradient of venous flow. Changes in peripheral resistance occurring near the right atrium greatly affect venous return, whereas changes in peripheral resistance occurring at progressively greater distances from the right atrium have progressively less effect on venous return. The various factors affecting venous return were expressed in a formula. It was illustrated how venous return curves can be equated with cardiac response curves; by equating these curves both the cardiac output and the right atrial pressure are simultaneously determined.