Ginsennoside Rd Attenuates Cognitive Dysfunction in a Rat Model of Alzheimer's Disease
Ginsennoside Rd Attenuates Cognitive Dysfunction in a Rat Model of Alzheimer's Disease
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DOI：
10.1007/s11064-012-0866-2
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发表时间：
2012-12-01
影响因子：
4.4
通讯作者：
Zhao, Gang
中科院分区：
文献类型：
--
作者：
Liu, Juanfang;Yan, Xiaodong;Zhao, Gang
阿尔茨海默病是一种神经退行性疾病，其特征是β -淀粉样蛋白的产生和tau蛋白的过度磷酸化。炎症和细胞凋亡的严重程度与早发阿尔茨海默病的年龄高度相关，也与认知能力下降有关。本研究旨在探讨中药人参皂苷Rd对β -淀粉样肽1-40诱导的阿尔茨海默病大鼠模型是否具有预防认知缺陷和神经保护作用。将聚集的β -淀粉样肽1-40注入双侧海马，制备阿尔茨海默病动物模型。连续30 d每日腹腔注射人参皂苷Rd，可保护大鼠认知功能障碍，改善大鼠记忆功能。人参皂苷Rd对β -淀粉样肽1-40诱导的炎症有明显的缓解作用。此外，人参皂苷Rd还可以下调caspase-3蛋白，减少β -淀粉样蛋白1-40注射后的细胞凋亡。本研究结果表明人参皂苷Rd预处理对β -淀粉样肽1-40诱导的AD模型大鼠具有神经保护作用。
Alzheimer's disease is a neurodegenerative disease characterized by the production of beta-amyloid proteins and hyperphosphorylation of tau protein. Inflammation and apoptotic severity were highly correlated with earlier age at onset of Alzheimer's disease and were also associated with cognitive decline. This study aims to examine whether the traditional Chinese medicine ginsennoside Rd could prevent cognitive deficit and take neuroprotective effects in beta-amyloid peptide 1-40-induced rat model of Alzheimer's disease. To produce Alzheimer's disease animal model, aggregated beta-amyloid peptide 1-40 injected into hippocampus bilaterally. Ginsennoside Rd protected their cognitive impairment and improved their memory function by daily intraperitoneal injection for 30 days consecutively. In addition, ginsennoside Rd alleviated the inflammation induced by beta-amyloid peptide 1-40. Furthermore, ginsennoside Rd played a role in the down-regulation of caspase-3 proteins and reduced the apoptosis that normally followed beta-amyloid peptide 1-40 injection. The results of this study showed that the pretreatment of ginsennoside Rd had neuroprotective effects in beta-amyloid peptide 1-40-induced AD model rat.