Wnt and BMP Signaling Crosstalk in Regulating Dental Stem Cells: Implications in Dental Tissue Engineering.
Wnt and BMP Signaling Crosstalk in Regulating Dental Stem Cells: Implications in Dental Tissue Engineering.
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Wnt 和 BMP 信号串扰调节牙干细胞：对牙组织工程的影响
DOI：
10.1016/j.gendis.2016.09.004
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发表时间：
2016-12
期刊：
影响因子：
6.8
通讯作者：
Ji P
中科院分区：
文献类型：
--
作者：
Zhang F;Song J;Zhang H;Huang E;Song D;Tollemar V;Wang J;Wang J;Mohammed M;Wei Q;Fan J;Liao J;Zou Y;Liu F;Hu X;Qu X;Chen L;Yu X;Luu HH;Lee MJ;He TC;Ji P
牙齿是一个复杂的硬组织器官，由多种细胞类型组成，这些细胞类型受重要的信号通路如Wnt和BMP信号通路的调节。牙齿或牙周组织的严重损伤和/或缺失可能会严重影响美观、基本口腔功能和生活质量。再生牙科在治疗口腔/牙科疾病方面有很大的希望。在过去的十年里，我们对牙齿干细胞的生物学特性以及调控干细胞自我更新和分化的信号传导机制的理解沿着迅速扩展。本文首先对牙髓干细胞、根尖乳头干细胞、乳牙脱落干细胞、牙囊前体细胞、牙周膜干细胞、牙槽骨间充质干细胞和牙龈间充质干细胞等7种牙源性干细胞的生物学特性进行综述。然后，我们专注于这些干细胞是如何调节骨形态发生蛋白（BMP）和/或Wnt信号通过检查这些途径之间的相互作用。最后，我们分析了利用口腔/牙齿干细胞的牙齿组织工程策略的现状，利用BMP和Wnt通路之间的相互作用。我们还强调了在牙科干细胞达到任何临床应用之前必须解决的挑战。因此，我们可以期待在未来十年内在再生牙科方面取得重大进展。
Tooth is a complex hard tissue organ and consists of multiple cell types that are regulated by important signaling pathways such as Wnt and BMP signaling. Serious injuries and/or loss of tooth or periodontal tissues may significantly impact aesthetic appearance, essential oral functions and the quality of life. Regenerative dentistry holds great promise in treating oral/dental disorders. The past decade has witnessed a rapid expansion of our understanding of the biological features of dental stem cells, along with the signaling mechanisms governing stem cell self-renewal and differentiation. In this review, we first summarize the biological characteristics of seven types of dental stem cells, including dental pulp stem cells, stem cells from apical papilla, stem cells from human exfoliated deciduous teeth, dental follicle precursor cells, periodontal ligament stem cells, alveolar bone-derived mesenchymal stem cells (MSCs), and MSCs from gingiva. We then focus on how these stem cells are regulated by bone morphogenetic protein (BMP) and/or Wnt signaling by examining the interplays between these pathways. Lastly, we analyze the current status of dental tissue engineering strategies that utilize oral/dental stem cells by harnessing the interplays between BMP and Wnt pathways. We also highlight the challenges that must be addressed before the dental stem cells may reach any clinical applications. Thus, we can expect to witness significant progresses to be made in regenerative dentistry in the coming decade.