Cyanidin-3-glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2.
Cyanidin-3-glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2.
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DOI：
10.1186/1476-4598-9-285
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发表时间：
2010-10-29
期刊：
影响因子：
37.3
通讯作者：
Luo J
中科院分区：
文献类型：
--
作者：
Xu M;Bower KA;Wang S;Frank JA;Chen G;Ding M;Wang S;Shi X;Ke Z;Luo J
Ethanol is a tumor promoter. Both epidemiological and experimental studies suggest that ethanol may enhance the metastasis of breast cancer cells. We have previously demonstrated that ethanol increased the migration/invasion of breast cancer cells expressing high levels of ErbB2. Amplification of ErbB2 is found in 20-30% of breast cancer patients and is associated with poor prognosis. We sought to identify agents that can prevent or ameliorate ethanol-induced invasion of breast cancer cells. Cyanidin-3-glucoside (C3G), an anthocyanin present in many vegetables and fruits, is a potent natural antioxidant. Ethanol exposure causes the accumulation of intracellular reactive oxygen species (ROS). This study evaluated the effect of C3G on ethanol-induced breast cancer cell migration/invasion. C3G attenuated ethanol-induced migration/invasion of breast cancer cells expressing high levels of ErbB2 (BT474, MDA-MB231 and MCF7ErbB2) in a concentration dependent manner. C3G decreased ethanol-mediated cell adhesion to the extracellular matrix (ECM) as well as the amount of focal adhesions and the formation of lamellipodial protrusion. It inhibited ethanol-stimulated phosphorylation of ErbB2, cSrc, FAK and p130Cas, as well as interactions among these proteins. C3G abolished ethanol-mediated p130Cas/JNK interaction. C3G blocks ethanol-induced activation of the ErbB2/cSrc/FAK pathway which is necessary for cell migration/invasion. C3G may be beneficial in preventing/reducing ethanol-induced breast cancer metastasis.
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DOI：
10.1083/jcb.200504124
发表时间：
2005-11-07
期刊：
The Journal of cell biology
影响因子：
--
作者：
Benlimame N;He Q;Jie S;Xiao D;Xu YJ;Loignon M;Schlaepfer DD;Alaoui-Jamali MA
通讯作者：
Alaoui-Jamali MA
影响因子：
6.4
作者：
Ke, Zunji;Lin, Hong;Luo, Jia
通讯作者：
Luo, Jia
影响因子：
3
作者：
Marczylo, Timothy H.;Cooke, Darren;Gescher, Andreas J.
通讯作者：
Gescher, Andreas J.
影响因子：
4.8
作者：
Takino, T;Nakada, M;Sato, H
通讯作者：
Sato, H
影响因子：
3.7
作者：
Chen, Gang;Bower, Kimberly A.;Xu, Mei;Ding, Min;Shi, Xianglin;Ke, Zun-Ji;Luo, Jia
通讯作者：
Luo, Jia