Synthesis and anticancer evaluation of bis(benzimidazoles), bis(benzoxazoles), and benzothiazoles
Synthesis and anticancer evaluation of bis(benzimidazoles), bis(benzoxazoles), and benzothiazoles
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DOI：
10.1016/j.bmc.2006.05.007
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发表时间：
2006-09-01
影响因子：
3.5
通讯作者：
Chen, Chinpiao
中科院分区：
文献类型：
--
作者：
Huang, Shu-Ting;Hsei, I-Jen;Chen, Chinpiao
合成了四类UK-1类似物，并测定了它们对人A-549、BFTC-905、RD、MES-SA和HeLa癌细胞系的细胞毒性试验。结果显示，UK-1和这些类似物中的四种（15-18）对癌细胞系是有效的。特别地，化合物16比UK-1更有效地对抗A-549和HeLa细胞系，并且化合物15、17和18分别选择性地表现出对BFTV-905细胞（IC 50 9.6 μ M）、A-549细胞（IC 50 6.6 μ M）和MES-SA细胞（IC 50 9.2 μ M）的有效细胞毒活性。(c)2006爱思唯尔有限公司保留所有权利。
Four classes of UK-1 analogues were synthesized and their cytotoxicity testing against human A-549, BFTC-905, RD, MES-SA, and HeLa carcinoma cell lines was determined. The results revealed that UK-1 and four of these analogues (15-18) are potent against the cancer cell lines. In particular, compound 16 is more potent than UK-1 against A-549 and HeLa cell lines, and compounds 15, 17, and 18 selectively exhibit potent cytotoxic activity against the BFTV-905 cells (IC50 9.6 PM), A-549 cells (IC50 6.6 mu M), and MES-SA cells (IC50 9.2 mu M),respectively. (c) 2006 Elsevier Ltd. All rights reserved.