Behavioral and cerebrovascular effects of caffeine in patients with anxiety disorders.
Behavioral and cerebrovascular effects of caffeine in patients with anxiety disorders.
复制标题
咖啡因对焦虑症患者的行为和脑血管影响。
DOI：
10.1111/j.1600-0447.1990.tb01348.x
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发表时间：
1990
影响因子：
6.7
通讯作者：
Wilson,WH
中科院分区：
文献类型：
--
作者：
Mathew,RJ;Wilson,WH
咖啡因被认为会引起正常人和焦虑症患者的焦虑以及恐慌症患者的恐慌发作。这种药物还可以减少脑血流量（CBF）。研究结果表明，焦虑相关的脑血管收缩因子已被报道。我们研究了8名广泛性焦虑障碍患者、9名惊恐障碍患者和9名正常对照者静脉注射250毫克咖啡因（相当于2杯咖啡）引起的焦虑和CBF变化之间的关系。另一组9名正常志愿者在注射生理盐水前后也测量了脑血流。摄入咖啡因后，焦虑症患者并没有表现出焦虑和恐慌增加的迹象。接受咖啡因治疗的患者和对照组，而接受生理盐水治疗的正常对照组，都显示出明显的CBF下降。CBF的变化与情绪、自主神经活动和二氧化碳水平的变化无关。
Caffeine is believed to induce anxiety in normal people and anxiety disorder patients and panic attacks in panic disorder patients. The drug is also known to reduce cerebral blood flow (CBF). Findings suggesting an anxiety‐related cerebral vasoconstrictive factor have been reported. We examined the relationship between changes in anxiety and CBF induced by intravenously injecting 250 mg of caffeine (comparable to 2 cups of coffee) in 8 patients with generalized anxiety disorder, 9 patients with panic disorder and 9 normal controls. CBF measurements were also obtained before and after an injection of normal saline in another group of 9 normal volunteers. The anxiety disorder patients did not show any evidence of increase in anxiety and panic after caffeine. Both patients and controls who received caffeine but not normal controls who received saline showed significant CBF decrease. The CBF changes were unrelated to changes in mood, autonomic activity and carbon dioxide levels.