The Early Indicators of Functional Decrease in Mild Cognitive Impairment
The Early Indicators of Functional Decrease in Mild Cognitive Impairment
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DOI：
10.3389/fnagi.2016.00193
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发表时间：
2016-08-12
影响因子：
4.8
通讯作者：
Mourey, France
中科院分区：
文献类型：
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作者：
Kubicki, Alexandre;Fautrelle, Lilian;Mourey, France
目的：轻度认知功能障碍（MCI）患者的运动功能缺陷与认知功能障碍相关。在这项研究中，我们的目的是测试在功能未受损的MCI患者的手臂指向运动参与肌肉协同作用的完整性。我们假设，早期运动指标存在于这个人群中在临床前level.Methods：收集11个肌肉在3组：年轻人（YA），老年人（OA），MCI患者的肌电图信号。OA组和MCI组的功能状态相同。结果：MCI组左内斜肌的激活早于OA组，MCI组左内斜肌的激活早于OA组和YA组。MCI和OA组之间肌肉协同作用的时间差异与MCI患者的执行功能有关，通过连线测试进行评估。此外，结果显示延迟激活的右股二头肌和右竖脊肌在13 MCI和OA相比，YA。解释：电机程序的变化突出显示在我们的病人MCI组表明，离散修改的电机命令似乎存在，即使在没有功能障碍。我们的研究结果没有显示MCI患者肌肉激活延迟的迹象，而是突出了几个躯干肌肉的早期激活。
Objectives: Motor deficiency is associated with cognitive frailty in patients with Mild Cognitive Impairments (MCI). In this study we aimed to test the integrity in muscle synergies involved in an arm-pointing movement in functionally unimpaired MCI patients. We hypothesized that early motor indicators exist in this population at a preclinical level.Methods: Electromyographic signals were collected for 11 muscles in 3 groups: Young Adults (YA), Older Adults (OA), and MCI patients. The OA and MCI groups presented the same functional status. Each subject performed 20 arm-pointing movements from a standing position.Results: The main differences were (1) an earlier activation of the left Obliquus internus in MCI compared with OA group, (2) an earlier activation for the MCI compared with both OA and YA. The temporal differences in muscle synergies between MCI and OA groups were linked with executive functions of MCI patients, assessed by the trail making test. Moreover, the results show a delayed activation of the right Biceps Femoris and the right Erector Spinae at 13 in MCI and OA compared with YA.Interpretation: The motor program changes highlighted in our patient MCI group suggest that discrete modifications of the motor command seem to exist even in the absence of functional impairment. Instead of showing an indication of delayed muscle activation in the MCI patients, our results highlight some early activation of several trunk muscles.