Morphometry of the amusic brain: a two-site study
Morphometry of the amusic brain: a two-site study
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DOI：
10.1093/brain/awl204
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发表时间：
2006-10-01
期刊：
影响因子：
14.5
通讯作者：
Peretz, Isabelle
中科院分区：
文献类型：
--
作者：
Hyde, Krista L.;Zatorre, Robert J.;Peretz, Isabelle
先天性音乐失听症（或音聋）是一种终身残疾，它阻止了其他正常功能的个体发展基本的音乐技能。行为证据表明，先天性失乐症是由于音高处理的严重缺陷，但对这种情况的神经相关性知之甚少。本研究的目的是探讨结构神经相关的先天性失乐症。为了这个目的，基于体素的形态测量学被用来检测大脑解剖学差异amusic个人相对于音乐完整的控制，通过分析T-1加权磁共振图像从两个独立的样本的主题。结果是一致的，在强调减少白色物质浓度在右额下回的音乐失乐症个体的样品。这种解剖学上的异常与基于音高的音乐任务的表现有关。结果与神经影像学结果一致，表明右下额叶区域参与音高编码和旋律音高记忆。我们认为，目前的结果是一个基于右半球的网络中的贫困通信的结果，该网络涉及下额叶皮层和右听觉皮层。此外，这些数据表明，右额叶脑区白色物质束的完整性是获得正常音乐能力的关键。
Congenital amusia (or tone deafness) is a lifelong disability that prevents otherwise normal-functioning individuals from developing basic musical skills. Behavioural evidence indicates that congenital amusia is due to a severe deficit in pitch processing, but very little is known about the neural correlates of this condition. The objective of the present study was to investigate the structural neural correlates of congenital amusia. To this aim, voxel-based morphometry was used to detect brain anatomical differences in amusic individuals relative to musically intact controls, by analysing T-1-weighted magnetic resonance images from two independent samples of subjects. The results were consistent across samples in highlighting a reduction in white matter concentration in the right inferior frontal gyrus of amusic individuals. This anatomical anomaly was correlated with performance on pitch-based musical tasks. The results are consistent with neuroimaging findings implicating right inferior frontal regions in musical pitch encoding and melodic pitch memory. We conceive the present results as a consequence of an impoverished communication in a right-hemisphere-based network involving the inferior frontal cortex and the right auditory cortex. Moreover, the data point to the integrity of white matter tracts in right frontal brain areas as being key in acquiring normal musical competence.