Synthesis and characterization of novel N-phenylacetamide bearing 1,2,4-triazole derivatives as potential antimicrobial agents
Synthesis and characterization of novel N-phenylacetamide bearing 1,2,4-triazole derivatives as potential antimicrobial agents
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DOI：
10.1007/s40242-017-6327-3
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发表时间：
2017-01
影响因子：
3.1
通讯作者：
Li Bochao;Lin Xinrui;Zhang Yumin;Z. Dawei;X. Yang;Lin Feng
中科院分区：
文献类型：
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作者：
Li Bochao;Lin Xinrui;Zhang Yumin;Z. Dawei;X. Yang;Lin Feng
合成了一系列新的1-取代苯基-2-（1H-1,2,4-三唑-1-基）乙酮衍生物3a - 3f，并通过IR、1H NMR、13C NMR和HRMS对其结构进行了表征。测定了其对细菌和真菌的抑菌活性。体外抑菌评价表明，5个化合物（3b - 3f）对真菌有抑制生长作用，其中3个化合物（3b、3c和3e）对革兰氏阴性菌有特殊抑菌效果。
A new series of 1-substituted phenyl-2-(1H-1,2,4-triazol-1-yl)ethanone derivatives3a―3f was synthe-sized and their structures were characterized by IR,1H NMR,13C NMR and HRMS spectral analysis. Antimicrobial activities of the derivatives were measured against both bacteria and fungi.In vitroantifungal evaluation showed that five compounds(3b―3f) had growth inhibitory effects on the tested fungus, and three of them(3b,3c and3e) showed special efficacy against Gram negative bacteria.