What can neurons do for their brain? Communicate selectivity with bursts
What can neurons do for their brain? Communicate selectivity with bursts
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DOI：
10.1007/s12064-012-0165-0
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发表时间：
2013-03-01
影响因子：
1.1
通讯作者：
Tononi, Giulio
中科院分区：
文献类型：
--
作者：
Balduzzi, David;Tononi, Giulio
大脑皮层深处的神经元极间接地与环境相互作用；它们接收和产生的棘波是由数百万其他神经元进行前后处理的。这篇论文提出了两个信息论的约束来指导棘波的产生，这两个约束有助于确保皮层深处的爆发活动与环境中的事件有意义地相关。首先，神经元应该强调突发性的选择性反应。其次，神经元应该通过突发性放电来传播选择性输入，以对它们做出反应。我们的研究表明，这些限制条件对于突发控制皮层内的信息传递是必要的，从而提供了一种底物，允许神经元在彼此之间分配信用。最后，由于突触的可塑性降低了神经元选择性爆发的能力，我们认为对突触重量的动态平衡调节是必要的，最好在睡眠期间离线执行。
Neurons deep in cortex interact with the environment extremely indirectly; the spikes they receive and produce are pre- and post-processed by millions of other neurons. This paper proposes two information-theoretic constraints guiding the production of spikes, that help ensure bursting activity deep in cortex relates meaningfully to events in the environment. First, neurons should emphasize selective responses with bursts. Second, neurons should propagate selective inputs by burst-firing in response to them. We show the constraints are necessary for bursts to dominate information-transfer within cortex, thereby providing a substrate allowing neurons to distribute credit amongst themselves. Finally, since synaptic plasticity degrades the ability of neurons to burst selectively, we argue that homeostatic regulation of synaptic weights is necessary, and that it is best performed offline during sleep.