Maternal MDMA administration in mice leads to neonatal growth delay.
Maternal MDMA administration in mice leads to neonatal growth delay.
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DOI：
10.2131/jts.39.33
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发表时间：
2014-02
期刊：
影响因子：
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通讯作者：
A. Kaizaki;Sachiko Tanaka;Takemi Yoshida;S. Numazawa
中科院分区：
文献类型：
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作者：
A. Kaizaki;Sachiko Tanaka;Takemi Yoshida;S. Numazawa
3，4-亚甲二氧基甲基苯丙胺（MDMA）是一种精神活性娱乐药物，被广泛滥用。众所周知，MDMA会导致多巴胺能神经末梢的神经毒性损伤。然而，MDMA对妊娠和新生动物的影响仍然未知。因此，我们研究了妊娠期暴露于MDMA对幼崽出生、生长和行为的影响。雌性BALB/c小鼠从妊娠第1天至出生后第21天（P）经口给予水（10 ml/kg）或MDMA（20 mg/10 ml/kg）。MDMA没有影响出生率，但幼崽的存活率显著下降。在P3-P21期间，在MDMA给药母鼠的幼仔中观察到体重增量显著降低。母亲的MDMA治疗引起衰减悬崖回避反应和减少运动功能的幼崽，确定了线悬挂测试。这些结果表明，MDMA治疗在怀孕和哺乳期造成生长迟缓和运动神经元功能障碍的小鼠幼崽。
The psychoactive recreational drug 3,4-methylenedioxymethamphetamine (MDMA) is widely abused. The fact that MDMA induces neurotoxic damage in serotonergic nerve endings is well known. However, the effects of MDMA on pregnant and neonatal animals remain unknown. Therefore, we studied the effects of gestational exposure to MDMA on birth, growth, and behavior of pups. Female BALB/c mice were orally administered either water (10 ml/kg) or MDMA (20 mg/10 ml/kg) from gestational day 1 to postnatal day (P) 21. MDMA did not affect the birth rate, but the survival rate of the pups significantly decreased. A significant reduction in body weight gain was observed in pups from MDMA-administered dams during P3-P21. Maternal MDMA treatment caused an attenuated cliff avoidance reaction and decreased motor function in the pups, as determined by the wire hanging test. These results suggest that MDMA treatment during pregnancy and lactation causes growth retardation and dysfunction of motor neurons in mouse pups.