Neuropeptide S receptor deficiency modulates spontaneous locomotor activity and the acoustic startle response
Neuropeptide S receptor deficiency modulates spontaneous locomotor activity and the acoustic startle response
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DOI：
10.1016/j.bbr.2010.09.022
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发表时间：
2011-02-02
影响因子：
2.7
通讯作者：
Sailer, Andreas W.
中科院分区：
文献类型：
--
作者：
Fendt, Markus;Buchi, Melanie;Sailer, Andreas W.
本研究调查了杂合和纯合的神经肽S受体（Npsr）缺陷的C57 BL/6小鼠的表型在可卡因和可卡因诱导的多动症，自发和反应性运动活动，高架十字迷宫，条件性恐惧，和前脉冲抑制的声惊吓反应。在Npsr缺陷小鼠中，观察到自发运动活动和惊吓幅度的强烈减少;杂合子小鼠具有中间表型。在其他实验中，Npsr缺陷导致没有或仅导致非常适度的表型。这些结果支持神经肽S在调节运动活动中的重要作用。(C)2010爱思唯尔有限公司版权所有。
The present study investigated the phenotype of heterozygous and homozygous neuropeptide S receptor (Npsr) deficient C57BL/6 mice in NPS- and cocaine induced hyperactivity, spontaneous and reactive locomotor activity, elevated plus maze, conditioned fear, and prepulse inhibition of the acoustic startle response. In Npsr-deficient mice, a strong reduction of spontaneous locomotor activity and of the startle magnitude was observed; heterozygous mice had an intermediate phenotype. In the other experiments, Npsr deficiency leads to no or only a very modest phenotype. These results support an important role of neuropeptide S in regulating locomotor activity. (C) 2010 Elsevier B.V. All rights reserved.