Thylakoid Membranes with Unique Photosystems Used to Simultaneously Produce Self-Supplying Oxygen and Singlet Oxygen for Hypoxic Tumor Therapy
Thylakoid Membranes with Unique Photosystems Used to Simultaneously Produce Self-Supplying Oxygen and Singlet Oxygen for Hypoxic Tumor Therapy
复制标题
具有独特光系统的类囊体膜可同时产生自供氧和单线态氧用于缺氧肿瘤治疗
DOI：
10.1002/adhm.202001666
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发表时间：
2021-01-14
影响因子：
10
通讯作者：
Zhang, Haiyuan
中科院分区：
文献类型：
--
作者：
Cheng, Yan;Zheng, Runxiao;Zhang, Haiyuan
光动力疗法(PDT)的疗效受到低氧肿瘤氧气水平不足的严重限制。尽管已经设计了各种PDT纳米系统来传递或产生O-2以支持活性氧物种(ROS)的形成，但氧-2产生和ROS形成不同步的特点仍然导致PDT效率较低。本文将叶绿体的类囊体膜修饰在上转换纳米粒子(UCNPs)上，形成UCTM纳米粒子，旨在实现时空同步的O-2自给和ROS产生。在980 nm激光照射下，UC纳米粒子可以发出红光，激活TM的光系统I和光系统II，其Z-型电子结构有助于水产生O-2，进而产生单线态氧(O-1(2))。UCTM纳米粒具有良好的生物相容性，在980 nm激光照射下能有效去除小鼠缺氧肿瘤。这项研究开发了一种基于光合作用的新的PDT策略用于缺氧肿瘤的治疗。
Photodynamic therapy (PDT) efficacy has been dramatically limited by the insufficient oxygen (O-2) level in hypoxic tumors. Although various PDT nanosystems have been designed to deliver or produce O-2 in support of reactive oxygen species (ROS) formation, the feature of asynchronous O-2 generation and ROS formation still results in the low PDT efficacy. Herein, thylakoid membranes (TM) of chloroplasts is decorated on upconversion nanoparticles (UCNPs) to form UCTM NPs, aiming at realizing spatiotemporally synchronous O-2 self-supply and ROS production. Upon 980 nm laser irradiation, UC NPs can emit the red light to activate both photosystem-I and photosystem-II of TM, the Z-scheme electronic structure of which facilitates water to produce O-2 and further to singlet oxygen (O-1(2)). UCTM NPs showed excellent biocompatibility, and can effectively remove the hypoxic tumor of mice upon 980 nm laser irradiation. This study develops a new PDT strategy for hypoxic tumor therapy based on photosynthesis.