New serotypes of adenoviral vectors.
New serotypes of adenoviral vectors.
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发表时间：
2006-10
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通讯作者：
D. Stone;A. Lieber
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作者：
D. Stone;A. Lieber
自从首次证明重组腺病毒（Ad）载体可以通过将外源基因插入Ad基因组中产生以来，它们已被广泛用作真核表达载体和治疗性基因传递载体。最初，Ad载体是基于人类Ad5血清型的，虽然目前大多数使用的Ad载体仍然基于Ad5，但最近的研究突出了一系列限制这些载体有效性和安全性的问题。为了避免与基于ad5的载体相关的问题，新的载体利用了各种来自人类和非人类的ad。本文综述了近年来非ad5基载体的研究进展。
Since it was first demonstrated that recombinant adenovirus (Ad) vectors could be generated by inserting foreign genes into Ad genomes, they have been extensively used as eukaryotic expression vectors and therapeutic gene delivery vehicles. Originally, Ad vectors were based on the human Ad5 serotype and while most currently used Ad vectors are still based on Ad5, recent research has highlighted a series of problems that limit the efficacy and safety of these vectors. To circumvent the problems associated with Ad5-based vectors, new vectors have utilized various Ads of both human and nonhuman origin. In this review we introduce the recent advances made in the development of non-Ad5-based vectors.