Two prospective studies found that elevated 2-hr glucose predicted male mortality independent of fasting glucose and HbAlc
Two prospective studies found that elevated 2-hr glucose predicted male mortality independent of fasting glucose and HbAlc
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DOI：
10.1016/j.jclinepi.2003.10.007
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发表时间：
2004-06-01
影响因子：
7.2
通讯作者：
Tuomilehto, J
中科院分区：
文献类型：
--
作者：
Qiao, Q;Dekker, JM;Tuomilehto, J
目的：为了量化2小时血糖、空腹血糖（FPG）和HbA 1c升高对全因死亡率的相对贡献。研究设计和设置：对两项前瞻性研究进行联合分析，基线血糖测量。对应于HbA 1c增加一个标准差的多变量校正风险比（HR）为1.14（95% CI 1.03-1.25），FPG为1.08（0.98-1.19），2小时葡萄糖为1.15（1.05-1.27）。将2小时葡萄糖输入基于FPG和HbA 1c的模型显著改善了死亡率的预测，而一旦2小时葡萄糖进入模型，FPG和HbA 1c都没有增加显著信息。FPG受试者
Objective: To quantify the relative contribution of elevated 2-hr glucose, fasting glucose (FPG), and HbA1c to all-cause mortality.Study Design and Setting: A joint analysis of two prospective studies with baseline glycemia measurements.Results: The multivariate adjusted hazard ratios (HRs) corresponding to a one standard deviation increase in HbA1c were 1.14 (95% CI 1.03-1.25), 1.08 (0.98-1.19) for FPG and 1.15 (1.05-1.27) for 2-hr glucose, respectively. Entering the 2-hr glucose to the model based on the FPG and HbA1c significantly improved the prediction of mortality, whereas neither FPG, nor HbA1c added significant information once 2-hr glucose was in the models. In subjects with FPG