Genetic Determinants of Type 2 Diabetes in Asians.
Genetic Determinants of Type 2 Diabetes in Asians.
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DOI：
10.19070/2328-353x-si01001
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Wang T
中科院分区：
文献类型：
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作者：
Qi Q;Wang X;Strizich G;Wang T
2型糖尿病（T2D）已成为世界范围内的一个主要健康问题，在亚洲国家尤为严重。与欧洲人相比，在体重增加相同的情况下，亚洲人患糖尿病的年龄往往更小，发病率也高得多。全基因组关联研究（GWAS）已经确定了70多个与T2D相关的位点。虽然大多数GWAS结果是在欧洲血统人群中进行的，但最近亚洲人的GWAS对确定T2D易感位点做出了重要贡献。这些研究不仅证实了最初在欧洲人群中发现的T2D易感位点，而且还发现了新的易感位点，为疾病的病理生理学提供了新的见解。在本文中，我们回顾了在东亚和南亚进行的T2D的GWAS结果，并将其与欧洲人群进行了比较。目前发现的T2D基因变异似乎不能解释亚洲人比欧洲人更容易患T2D的现象，这表明需要对亚洲人群进行进一步的研究。
Type 2 diabetes (T2D) has become a major health problem throughout the world and the epidemic is particularly severe in Asian countries. Compared with European populations, Asians tend to develop diabetes at a younger age and at much higher incidence rates given the same amount of weight gain. Genome-wide association studies (GWAS) have identified over 70 loci associated with T2D. Although the majority of GWAS results were conducted in populations of European ancestry, recent GWAS in Asians have made important contributions to the identification of T2D susceptibility loci. These studies not only confirmed T2D susceptibility loci initially identified in European populations, but also identified novel susceptibility loci that provide new insights into the pathophysiology of diseases. In this article, we review GWAS results of T2D conducted in East and South Asians and compare them to those of European populations. Currently identified T2D genetic variants do not appear to explain the phenomenon that Asians are more susceptible to T2D than European populations, suggesting further studies in Asian populations are needed.