Outbreak of Vancomycin-resistant Enterococcus faecium in Interventional Radiology: Detection Through Whole-genome Sequencing-based Surveillance
Outbreak of Vancomycin-resistant Enterococcus faecium in Interventional Radiology: Detection Through Whole-genome Sequencing-based Surveillance
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DOI：
10.1093/cid/ciz666
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发表时间：
2020-06-01
影响因子：
11.8
通讯作者：
Harrison, Lee H.
中科院分区：
文献类型：
--
作者：
Sundermann, Alexander J.;Babiker, Ahmed;Harrison, Lee H.
背景资料。耐万古霉素肠球菌(VRE)是医院获得性感染的主要原因。介入放射学(IR)手术引起感染的风险没有很好的文献记载。对住院患者中临床分离的细菌进行全基因组测序(WGS)监测，可以识别以前未发现的疫情。我们分析了2016年11月至2017年11月的WGS监测数据，以寻找VRE传播的证据。发现了一个以前未被发现的10个基因相关的VRE(屎肠球菌)感染的聚集性。电子健康记录审查发现IR程序是一个潜在的来源。进行暴发疫情调查。在10名暴发患者中，9名接受了静脉(IV)造影剂IR手术
Background. Vancomycin-resistant enterococci (VRE) are a major cause of hospital-acquired infections. The risk of infection from interventional radiology (IR) procedures is not well documented. Whole-genome sequencing (WGS) surveillance of clinical bacterial isolates among hospitalized patients can identify previously unrecognized outbreaks.Methods. We analyzed WGS surveillance data from November 2016 to November 2017 for evidence of VRE transmission. A previously unrecognized cluster of 10 genetically related VRE (Enterococcus faecium) infections was discovered. Electronic health record review identified IR procedures as a potential source. An outbreak investigation was conducted.Results. Of the 10 outbreak patients, 9 had undergone an IR procedure with intravenous (IV) contrast