The AP2 domain of APETALA2 defines a large new family of DNA binding proteins in Arabidopsis
The AP2 domain of APETALA2 defines a large new family of DNA binding proteins in Arabidopsis
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DOI：
10.1073/pnas.94.13.7076
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发表时间：
1997-06-24
影响因子：
11.1
通讯作者：
Jofuku, KD
中科院分区：
文献类型：
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作者：
Okamuro, JK;Caster, B;Jofuku, KD
APETALA2（AP2）在拟南芥花和种子发育的控制中起重要作用，并编码一种推定的转录因子，该转录因子通过被称为AP2结构域的新型DNA结合基序而区分。在这项研究中，我们发现含有AP 2结构域或RAP 2（与AP 2相关）蛋白家族由拟南芥中至少12个基因编码。RAP 2基因编码两类蛋白，AP 2样蛋白和EREBP样蛋白，其由每个多肽中AP 2结构域的数量以及位于每个AP 2结构域内的称为YRG和RAYD元件的两个序列基序定义。RAP 2基因在花叶、花序茎和根中差异表达。此外，在营养组织中至少三个RAP 2基因的表达受AP 2控制。因此，与其他花同源异型基因不同，AP 2在生殖和营养发育中都具有活性。
APETALA2 (AP2) plays an important role in the control of Arabidopsis flower and seed development and encodes a putative transcription factor that is distinguished by a novel DNA binding motif referred to as the AP2 domain. in this study we show that the AP2 domain containing or RAP2 (related to AP2) family of proteins is encoded by a minimum of 12 genes in Arabidopsis. The RAP2 genes encode two classes of proteins, AP2-like and EREBP-like, that are defined by the number of AP2 domains in each polypeptide as well as by two sequence motifs referred to as the YRG and RAYD elements that are located within each AP2 domain, RAP2 genes are differentially expressed in flower leaf, inflorescence stem, and root. Moreover, the expression of at least three RAP2 genes in vegetative tissues are controlled by AP2. Thus, unlike other floral homeotic genes, AP2 is active juring both reproductive and vegetative development.