CLONING OF THE CHROMOSOME BREAKPOINT OF NEOPLASTIC B-CELLS WITH THE T(14-18) CHROMOSOME-TRANSLOCATION
CLONING OF THE CHROMOSOME BREAKPOINT OF NEOPLASTIC B-CELLS WITH THE T(14-18) CHROMOSOME-TRANSLOCATION
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DOI：
10.1126/science.6093263
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
CROCE, CM
中科院分区：
文献类型：
--
作者：
TSUJIMOTO, Y;FINGER, LR;CROCE, CM
从一个急性B细胞白血病细胞系中，获得了位于14号染色体Ig重链基因重链连接区两侧的18号染色体特异的DNA探针。该探针在白血病细胞和滤泡性淋巴瘤细胞中检测到(14；18)染色体易位的同源DNA片段重排，而在其他肿瘤或正常B或T细胞中未检测到该DNA片段重排。该探针似乎识别了bcl1，这是位于18号染色体(Q21带)上的一个基因位点，与已知的癌基因无关，可能在这种易位的B细胞肿瘤的发病机制中起重要作用。
From an acute B-cell leukemia cell line, a DNA probe was obtained that was specific for chromosome 18 and flanked the heavy chain joining region of the Ig heavy chain locus on chromosome 14. This probe detected rearrangement of the homologous DNA segment in the leukemic cells and in follicular lymphoma cells with the (14;18) chromosome translocation but not in other neoplastic or normal B or T cells. The probe appears to identify bcl-1, a gene locus on chromosome 18 (band q21) that is unrelated to known oncogenes and may be important in the pathogenesis of B-cell neoplasms with this translocation.