The Functional Polymorphism 844 A>G in FcαRI (CD89) Does Not Contribute to Systemic Sclerosis or Rheumatoid Arthritis Susceptibility
The Functional Polymorphism 844 A>G in FcαRI (CD89) Does Not Contribute to Systemic Sclerosis or Rheumatoid Arthritis Susceptibility
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DOI：
10.3899/jrheum.100427
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发表时间：
2011-03-01
影响因子：
3.9
通讯作者：
Radstake, Timothy R. D. J.
中科院分区：
文献类型：
--
作者：
Broen, Jasper C. A.;Coenen, Marieke J. H.;Radstake, Timothy R. D. J.
目标。目的探讨Fc(α) r844a >g功能多态性在类风湿关节炎（RA）和系统性硬化症（SSc）易感性遗传易感性中的作用。研究人群包括1401名SSc患者、642名RA患者和1317名健康对照。Fc(α)RI （CD89）单核苷酸多态性rs16986050通过焦磷酸测序进行基因分型。我们观察到与对照组相比，RA和SSc的基因型和等位基因频率没有显著偏差。荟萃分析和显性和隐性模型得出了类似的阴性结果。我们的数据显示，FcaRI 844a >g多态性与SSc或RA易感性无关。（首次发布2010年12月15日；journal Rheumatol 2011;38:446-9; doi:10.3899/ jrheumat. 100427）
Objective. To investigate the role of the Fc(alpha)RI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility.Methods. The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc(alpha)RI (CD89) single-nucleotide polymorphism rs16986050 was geno-typed by pyrosequencing.Results. We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results.Conclusion. Our data show that the FcaRI 844 A>G polymorphism is not associated with SSc or RA susceptibility. (First Release Dec 15 2010; J Rheumatol 2011;38:446-9; doi:10.3899/jrheum.100427)