Monte Carlo simulations of plasma membrane corral-induced EGFR clustering
Monte Carlo simulations of plasma membrane corral-induced EGFR clustering
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DOI：
10.1016/j.jbiotec.2010.12.009
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发表时间：
2011-02-10
影响因子：
4.1
通讯作者：
Edwards, Jeremy S.
中科院分区：
文献类型：
--
作者：
Costa, Michelle N.;Radhakrishnan, Krishnan;Edwards, Jeremy S.
实验证据表明，细胞膜是一种高度组织化的结构，由底层膜细胞骨架（MSK）划分。细胞膜和细胞骨架之间的相互作用导致了“栅栏”模型，该模型被提出来解释膜区室化的某些方面。该模型假设MSK阻碍并限制受体和脂质在膜中的隔室的运动。然而，MSK对受体聚集、聚集和下游信号传导的影响仍不清楚。例如，一些证据表明MSK增强二聚化，而其他证据表明减少二聚化和信号传导。在这里，我们使用计算蒙特卡罗模拟来研究MSK密度和受体浓度对受体二聚化和聚集的影响。初步结果表明，MSK可能有潜力诱导受体聚集，这是一个功能的栅栏密度和受体浓度。(C)2010 Elsevier B.V.保留所有权利。
Experimental evidence suggests that the cell membrane is a highly organized structure that is compartmentalized by the underlying membrane cytoskeleton (MSK). The interaction between the cell membrane and the cytoskeleton led to the "picket-fence" model, which was proposed to explain certain aspects of membrane compartmentalization. This model assumes that the MSK hinders and confines the motion of receptors and lipids to compartments in the membrane. However, the impact of the MSK on receptor clustering, aggregation, and downstream signaling remains unclear. For example, some evidence suggests that the MSK enhances dimerization, while other evidence suggests decreased dimerization and signaling. Herein, we use computational Monte Carlo simulations to examine the effects of MSK density and receptor concentration on receptor dimerization and clustering. Preliminary results suggest that the MSK may have the potential to induce receptor clustering, which is a function of both picket-fence density and receptor concentration. (C) 2010 Elsevier B.V. All rights reserved.