Chromosome aberrations induced in human lymphocytes by ultrasoft Al (K) and C (K) X-rays.
Chromosome aberrations induced in human lymphocytes by ultrasoft Al (K) and C (K) X-rays.
复制标题
超软 Al (K) 和 C (K) X 射线在人类淋巴细胞中诱导染色体畸变。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
J. Thacker
中科院分区：
文献类型：
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作者：
R. Virsik;Ch. Schäfer;D. Harder;D. Goodhead;R. Cox;J. Thacker
本文研究了在非刺激状态下用超软X射线照射人外周血淋巴细胞诱发结构染色体畸变的作用。使用铝钾片(1.49keV)和碳钾片(0.28keV)。发现双着丝粒像差和过量无着丝粒碎片的频率随两种照射的吸收剂量近似线性增加。碳X射线比铝X射线更有效。双着丝粒的线性产额系数分别为(3.7×10~(-1))和(2.2×10~(-1))GY~(-1)。在低剂量时，这两种辐射在产生双着丝粒像差方面都比硬X射线更有效，但在高剂量时，铝X射线的效果不如硬X射线，因为硬X射线剂量响应的正曲率很大。这些实验中最重要的观察结果是，由碳X射线产生的低于280 eV的电子在产生双着丝粒像差方面是有效的。这意味着在小于7 nm的范围内发生约14个电离的单个局域能量事件能够产生交换像差。
Induction of structural chromosome aberrations was studied in human peripheral blood lymphocytes irradiated in the unstimulated state with ultrasoft X-rays. Aluminium K X-rays (1.49 ke V) and carbon K X-rays (0.28 ke V) were used. The frequencies of dicentric aberrations and of excess acentric fragments were found to increase approximately linearly with absorbed dose of both radiations. Carbon X-rays were more effective than aluminium X-rays. The corresponding linear yield coefficients for dicentrics are (3.7 X 10(-1)) Gy-1 and (2.2 X 10(-1)) Gy-1 respectively. AT low doses both these radiations are more effective than hard X-rays in producing dicentric aberrations, but at high doses aluminium X-rays are less effective than hard X-rays because of the large positive curvature of the hard X-ray dose-response. The most significant observation of these experiments is that electrons of less than 280 eV, produced by carbon X-rays, are efficient in producing dicentric aberrations. This implies that single local energy events of about 14 ionizations with in less than 7 nm are able to produce exchange aberrations.